An expedient, facile and simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles from the Baylis-Hillman bromides in aqueous media

被引：35

作者：

Basavaiah, Deevi ^{[1
,2
]}

Reddy, Kanumuri Ramesh ^{[2
]}

Kumaragurubaran, Nagaswamy ^{[2
]}

机构：

[1] Udyog Vihar Ind Area, Ranbaxy Lab Ltd, NDDR, Gurgaon 122015, Haryana, India

[2] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

NATURE PROTOCOLS | 2007年 / 2卷 / 11期

关键词：

D O I：

10.1038/nprot.2007.369

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This protocol is for an expedient and operationally simple one-pot synthesis of 2-methylenealkanoates and alkanenitriles in high yields from the corresponding Baylis-Hillman bromides. The reaction proceeds via the successive treatment with 1,4-diazabicyclo(2.2.2) octane (DABCO) for 15 min and sodium borohydride for 15 min in aqueous media [tetrahydrofuran (THF): H2O (1:1)] at room temperature.

引用

页码：2665 / 2676

页数：12

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