Harnessing neoantigen specific CD4 T cells for cancer immunotherapy

被引：49

作者：

Brightman, Spencer E. ^{[1
]}

Naradikian, Martin S. ^{[1
]}

Miller, Aaron M. ^{[1
]}

Schoenberger, Stephen P. ^{[1
]}

机构：

[1] La Jolla Inst Immunol, 9420 Athena Circle, La Jolla, CA 92037 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2020年 / 107卷 / 04期

关键词：

adoptive cell therapy; cancer vaccines; immune checkpoint blockade; neoantigens; TUMOR-INFILTRATING LYMPHOCYTES; EXOME ANALYSIS REVEALS; DENDRITIC CELLS; CTLA-4; BLOCKADE; PEPTIDE VACCINATION; ANTITUMOR-ACTIVITY; PD-1; B-CELL; CD8(+); ANTIGEN;

D O I：

10.1002/JLB.5RI0220-603RR

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to-date have focused on MHC class I-restricted peptide epitopes by which cytotoxic CD8(+) T lymphocytes (CTL) can directly recognize tumor cells. This strategy largely overlooks the critical role of MHC class II-restricted CD4(+) T cells as both positive regulators of CTL and other effector cell types, and as direct effectors of antitumor immunity. In this review, we will discuss the role of neoantigen specific CD4(+) T cells in cancer immunotherapy and how existing treatment modalities may be leveraged to engage this important T cell subset.

引用

页码：625 / 633

页数：9

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