Moving towards a Treatable Traits model of care for the management of obstructive airways diseases

被引：39

作者：

Agusti, Alvar ^{[1
,2
]}

Barnes, Neil ^{[3
,4
]}

Cruz, Alvaro A. ^{[5
]}

Gibson, Peter G. ^{[6
,7
]}

Heaney, Liam G. ^{[8
]}

Inoue, Hiromasa ^{[9
]}

Leather, David ^{[3
,4
]}

Martinez, Fernando J. ^{[10
]}

McDonald, Vanessa M. ^{[6
,7
]}

Oppenheimer, John ^{[11
]}

Papi, Alberto ^{[12
]}

Pavord, Ian D. ^{[13
,14
]}

Thomas, Mike ^{[15
]}

Walker, Samantha ^{[16
]}

Yates, Louisa ^{[3
,4
]}

机构：

[1] Univ Barcelona, Catedra Salud Resp, Resp Inst, Hosp Clin Barcelona, Barcelona, Spain

[2] CIBERES, Barcelona, Spain

[3] Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London, England

[4] Fundacao ProAR, Salvador, BA, Brazil

[5] Univ Fed Bahia, Salvador, BA, Brazil

[6] Univ Newcastle, Fac Hlth & Med, Prior Res Ctr Hlth Lungs, Callaghan, NSW, Australia

[7] Univ Newcastle, Fac Hlth & Med, Hunter Med Res Inst, Callaghan, NSW, Australia

[8] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Wellcome Wolfson Inst Expt Med, Belfast, Antrim, North Ireland

[9] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pulm Med, Kagoshima, Japan

[10] New York Presbyterian Weill Cornell Med Ctr, Pulm & Crit Care Med Div, New York, NY USA

[11] Rutgers New Jersey Med Sch, Dept Internal Med, Newark, NJ USA

[12] Univ Ferrara, Dept Translat Med, Resp Med, Ferrara, Italy

[13] Univ Oxford, Nuffield Dept Med, Resp Med Unit, Oxford, England

[14] Univ Oxford, Nuffield Dept Med, NIHR Oxford Resp BRC, Oxford, England

[15] Univ Southampton, Primary Care Res Ctr, Sch Primary Care Populat Sci & Med Educ, Southampton, Hants, England

[16] Asthma UK & British Lung Fdn Partnership, London, England

来源：

RESPIRATORY MEDICINE | 2021年 / 187卷

关键词：

Asthma; Biomarkers; COPD; Targeted therapy; RANDOMIZED CONTROLLED-TRIALS; EXHALED NITRIC-OXIDE; PULMONARY-DISEASE; SEVERE ASTHMA; TARGETED THERAPIES; EOSINOPHIL COUNTS; MILD ASTHMA; COPD; EXACERBATIONS; PRODUCTIVITY;

D O I：

10.1016/j.rmed.2021.106572

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airways diseases. Both are complex and heterogeneous. Traditionally, clinical guidelines have advocated a stepwise approach to pharmacotherapy of asthma and COPD, but there is increasing realization that both require a more personalized and precise management approach. To this end, a management strategy based on the so-called Treatable Traits has been proposed. Emerging evidence suggests that this model improves relevant outcomes in patients with chronic airway diseases but further research is needed to guide implementation. This review discusses the challenges, opportunities, and hurdles that its implementation will have to face.

引用

页数：8

共 71 条

[1] Inhaled corticosteroids in COPD: friend or foe? [J].

Agusti, Alvar ;

Fabbri, Leonardo M. ;

Singh, Dave ;

Vestbo, Jorgen ;

Celli, Bartolome ;

Franssen, Frits M. E. ;

Rabe, Klaus F. ;

Papi, Alberto .

EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (06)

[2] Treatable traits: toward precision medicine of chronic airway diseases [J].

Agusti, Alvar ;

Bel, Elisabeth ;

Thomas, Mike ;

Vogelmeier, Claus ;

Brusselle, Guy ;

Holgate, Stephen ;

Humbert, Marc ;

Jones, Paul ;

Gibson, Peter G. ;

Vestbo, Jorgen ;

Beasley, Richard ;

Pavord, Ian D. .

EUROPEAN RESPIRATORY JOURNAL, 2016, 47 (02) :410-419

[3]

[Anonymous], 2019, BRIT GUID MAN ASTHM

[4]

Asthma UK,, 2018, SLIPP NET REAL NET R

[5] Economic burden of asthma: A systematic review [J].

Bahadori K. ;

Doyle-Waters M.M. ;

Marra C. ;

Lynd L. ;

Alasaly K. ;

Swiston J. ;

FitzGerald J.M. .

BMC Pulmonary Medicine, 9 (1)

[6] Journal Club-COPD2020 Update. Global Initiative for Chronic Obstructive Lung Disease 2020 Report and the Journal of the COPD Foundation Special Edition, Moving to a New Definition for COPD: "COPDGene® 2019" [J].

Balkissoon, Ron .

CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION, 2020, 7 (01) :68-76

[7]

Beasley R, 2020, NEW ZEAL MED J, V133, P73

[8] Optimal Asthma Control: Time for a New Target [J].

Beasley, Richard ;

Braithwaite, Irene ;

Semprini, Alex ;

Kearns, Cilein ;

Weatherall, Mark ;

Pavord, Ian D. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201 (12) :1480-1487

[9] Controlled Trial of Budesonide-Formoterol as Needed for Mild Asthma [J].

Beasley, Richard ;

Holliday, Mark ;

Reddel, Helen K. ;

Braithwaite, Irene ;

Ebmeier, Stefan ;

Hancox, Robert J. ;

Harrison, Tim ;

Houghton, Claire ;

Oldfield, Karen ;

Papi, Alberto ;

Pavord, Ian D. ;

Williams, Mathew ;

Weatherall, Mark .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (21) :2020-2030

[10] Randomised controlled trials in severe asthma: selection by phenotype or stereotype [J].

Brown, Thomas ;

Jones, Thomas ;

Gove, Kerry ;

Barber, Clair ;

Elliott, Scott ;

Chauhan, Anoop ;

Howarth, Peter ;

Aitkin, L. ;

Babu, S. ;

Dennison, P. ;

Djukanovic, R. ;

Grainge, C. ;

Hewitt, L. ;

Jayasekera, N. ;

Kurukulaaratchy, R. ;

Kerley, S. ;

Lau, L. ;

Laws, D. ;

Owen, J. ;

Ray, E. ;

Reynish, D. ;

Rupani, H. ;

Scullion-Win, O. .

EUROPEAN RESPIRATORY JOURNAL, 2018, 52 (06)

← 1 2 3 4 5 6 7 8 →