Enantiospecific synthesis of analogues of the diketide intermediate of the erythromycin polyketide synthase (PKS)

被引：15

作者：

Harris, RC ^{[1
]}

Cutter, AL ^{[1
]}

Weissman, KJ ^{[1
]}

Hanefeld, U ^{[1
]}

Timoney, MC ^{[1
]}

Staunton, J ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 1998年 / 06期

关键词：

D O I：

10.1039/a800584b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The four stereoisomers of 3-hydroxy-2-methylpentanoic acid (1a-d) and the structurally modified acids 1e-j have been synthesised enantiospecifically and converted into p-nitrophenyl ester and thioester derivatives; as the activated derivatives; they are available for investigations into the substrate selectivity of polyketide synthase (PKS) domains.

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页码：283 / +

页数：2

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