AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients

被引：25

作者：

Alpermann, Tamara ^{[1
]}

Haferlach, Claudia ^{[1
]}

Eder, Christiane ^{[1
]}

Nadarajah, Niroshan ^{[1
]}

Meggendorfer, Manja ^{[1
]}

Kern, Wolfgang ^{[1
]}

Haferlach, Torsten ^{[1
]}

Schnittger, Susanne ^{[1
]}

机构：

[1] MLL, D-81377 Munich, Germany

来源：

LEUKEMIA RESEARCH | 2015年 / 39卷 / 03期

关键词：

AML; Trisomy; 8; Molecular mutations; Genetic stability; Prognosis; ACUTE MYELOID-LEUKEMIA; GENE-MUTATIONS; TRISOMY-8; PROGNOSIS; IMPACT; ABERRATIONS; KARYOTYPE; CANCER; AGE;

D O I：

10.1016/j.leukres.2014.11.026

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Trisomy 8 is the most frequent cytogenetically gained aberration in AML. We compared 79 adult de novo AML with trisomy 8 as the sole cytogenetic abnormality (+8sole) to 511 normal karyotype AML patients (NK). +8sole patients were older (p = 0.013), presented lower WBC counts (p = 0.010), harbored more often ASXL1 mutations (p < 0.001) and RUNX1 mutations (p = 0.009), but less frequent FLT3-ITD (p = 0.038), NAM mutations (p < 0.001) and double-mutated CEBPA (p = 0.038) than NK patients. No prognostic difference was found between +8sole and NK. With respect to genetic stability we found +8sole was instable, and molecular markers were either stable or gained in number and diversity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：265 / 272

页数：8

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