GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair

被引：42

作者：

Cai, Jiaying ^{[1
]}

Zhang, Hui ^{[1
]}

Hu, Yangnan ^{[1
]}

Huang, Zhichun ^{[1
]}

Wang, Yan ^{[9
]}

Xia, Yu ^{[9
]}

Chen, Xiaoyan ^{[1
]}

Guo, Jiamin ^{[1
]}

Cheng, Hong ^{[1
]}

Xia, Lin ^{[1
]}

Lu, Weicheng ^{[7
]}

Zhang, Chen ^{[8
]}

Xie, Jingdun ^{[7
]}

Wang, Huan ^{[2
]}

Chai, Renjie ^{[1
,3
,4
,5
,6
,8
]}

机构：

[1] Southeast Univ, Adv Inst Life & Hlth,Zhongda Hosp, Dept Otolaryngol Head & Neck Surg,State Key Lab B, Sch Life Sci & Technol,Jiangsu Prov High Tech Key, Nanjing 210096, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China

[3] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Otolaryngol Head & Neck Surg, Nanjing 210008, Peoples R China

[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Chengdu 610072, Peoples R China

[5] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China

[6] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100086, Peoples R China

[7] Sun Yat Sen Univ, Collaborat Innovat Canc Med, State Key Lab Oncol Southern China, Dept Anesthesiol,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China

[8] Capital Med Univ, Beijing Key Lab Neural Regenerat & Repair, Beijing 100069, Peoples R China

[9] Southeast Univ, Chien Shiung Wu Coll, Nanjing, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2022年 / 20卷 / 01期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

Conductive hydrogel; MXene; Microgroove structure; Neural stem cells; Spinal cord injury; NEURAL STEM-CELLS; TRANSPLANTATION;

D O I：

10.1186/s12951-022-01669-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.

引用

页数：13

共 42 条

[21] Healable, Degradable, and Conductive MXene Nanocomposite Hydrogel for Multifunctional Epidermal Sensors
Li, Xiaobin
He, Lingzhang
Li, Yanfei
Chao, Mingyuan
Li, Mingkun
Wan, Pengbo
Zhang, Liqun
[J]. ACS NANO, 2021, 15 (04) : 7765 - 7773
[22] Microglia-organized scar-free spinal cord repair in neonatal mice
Li, Yi
He, Xuelian
Kawaguchi, Riki
Zhang, Yu
Wang, Qing
Monavarfeshani, Aboozar
Yang, Zhiyun
Chen, Bo
Shi, Zhongju
Meng, Huyan
Zhou, Songlin
Zhu, Junjie
Jacobi, Anne
Swarup, Vivek
Popovich, Phillip G.
Geschwind, Daniel H.
He, Zhigang
[J]. NATURE, 2020, 587 (7835) : 613 - +
[23] Hydrophobic, Flexible, and Lightweight MXene Foams for High-Performance Electromagnetic-Interference Shielding
Liu, Ji
Zhang, Hao-Bin
Sun, Renhui
Liu, Yafeng
Liu, Zhangshuo
Zhou, Aiguo
Yu, Zhong-Zhen
[J]. ADVANCED MATERIALS, 2017, 29 (38)
[24] Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury
Lu, Paul
Wang, Yaozhi
Graham, Lori
McHale, Karla
Gao, Mingyong
Wu, Di
Brock, John
Blesch, Armin
Rosenzweig, Ephron S.
Havton, Leif A.
Zheng, Binhai
Conner, James M.
Marsala, Martin
Tuszynski, Mark H.
[J]. CELL, 2012, 150 (06) : 1264 - 1273
[25] Trimethylene carbonate-caprolactone conduit with poly-p-dioxanone microfilaments to promote regeneration after spinal cord injury
Novikova, Liudmila N.
Kolar, Mallappa K.
Kingham, Paul J.
Ullrich, Andreas
Oberhoffner, Sven
Renardy, Monika
Doser, Michael
Mueller, Erhard
Wiberg, Mikael
Novikov, Lev N.
[J]. ACTA BIOMATERIALIA, 2018, 66 : 177 - 191
[26] 2D MXene-Integrated 3D-Printing Scaffolds for Augmented Osteosarcoma Phototherapy and Accelerated Tissue Reconstruction
Pan, Shanshan
Yin, Junhui
Yu, Luodan
Zhang, Changqing
Zhu, Yufang
Gao, Youshui
Chen, Yu
[J]. ADVANCED SCIENCE, 2020, 7 (02)
[27] Bioinspired Multifunctional Spindle-Knotted Microfibers from Microfluidics
Shang, Luoran
Fu, Fanfan
Cheng, Yao
Yu, Yunru
Wang, Jie
Gu, Zhongze
Zhao, Yuanjin
[J]. SMALL, 2017, 13 (04)
[28] MXene-Integrated Microneedle Patches with Innate Molecule Encapsulation for Wound Healing
Sun, Lingyu
Fan, Lu
Bian, Feika
Chen, Guopu
Wang, Yuetong
Zhao, Yuanjin
[J]. RESEARCH, 2021, 2021
[29] Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
Swift, Joe
Ivanovska, Irena L.
Buxboim, Amnon
Harada, Takamasa
Dingal, P. C. Dave P.
Pinter, Joel
Pajerowski, J. David
Spinler, Kyle R.
Shin, Jae-Won
Tewari, Manorama
Rehfeldt, Florian
Speicher, David W.
Discher, Dennis E.
[J]. SCIENCE, 2013, 341 (6149)
[30] Electrical Stimuli in the Central Nervous System Microenvironment
Thompson, Deanna M.
Koppes, Abigail N.
Hardy, John G.
Schmidt, Christine E.
[J]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 16, 2014, 16 : 397 - 430

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