GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair

被引：53

作者：

Cai, Jiaying ^{[1
]}

Zhang, Hui ^{[1
]}

Hu, Yangnan ^{[1
]}

Huang, Zhichun ^{[1
]}

Wang, Yan ^{[9
]}

Xia, Yu ^{[9
]}

Chen, Xiaoyan ^{[1
]}

Guo, Jiamin ^{[1
]}

Cheng, Hong ^{[1
]}

Xia, Lin ^{[1
]}

Lu, Weicheng ^{[7
]}

Zhang, Chen ^{[8
]}

Xie, Jingdun ^{[7
]}

Wang, Huan ^{[2
]}

Chai, Renjie ^{[1
,3
,4
,5
,6
,8
]}

机构：

[1] Southeast Univ, Adv Inst Life & Hlth,Zhongda Hosp, Dept Otolaryngol Head & Neck Surg,State Key Lab B, Sch Life Sci & Technol,Jiangsu Prov High Tech Key, Nanjing 210096, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 8, Shenzhen 518033, Peoples R China

[3] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Otolaryngol Head & Neck Surg, Nanjing 210008, Peoples R China

[4] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Chengdu 610072, Peoples R China

[5] Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China

[6] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100086, Peoples R China

[7] Sun Yat Sen Univ, Collaborat Innovat Canc Med, State Key Lab Oncol Southern China, Dept Anesthesiol,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China

[8] Capital Med Univ, Beijing Key Lab Neural Regenerat & Repair, Beijing 100069, Peoples R China

[9] Southeast Univ, Chien Shiung Wu Coll, Nanjing, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2022年 / 20卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Conductive hydrogel; MXene; Microgroove structure; Neural stem cells; Spinal cord injury; NEURAL STEM-CELLS; TRANSPLANTATION;

D O I：

10.1186/s12951-022-01669-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.

引用

页数：13

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