Direct oral anticoagulants and venous thromboembolism

被引：21

作者：

Franchini, Massimo ^{[1
]}

Mannucci, Pier Mannuccio ^{[2
,3
]}

机构：

[1] Carlo Poma Hosp, Dept Transfus Med & Hematol, Mantua, Italy

[2] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Angelo Bianchi Bonomi Hemophilia & Thrombosis Ctr, Milan, Italy

[3] Univ Milan, Milan, Italy

来源：

EUROPEAN RESPIRATORY REVIEW | 2016年 / 25卷 / 141期

关键词：

FACTOR XA INHIBITOR; TOTAL KNEE ARTHROPLASTY; TOTAL HIP-ARTHROPLASTY; VITAMIN-K ANTAGONISTS; DEEP-VEIN THROMBOSIS; DABIGATRAN ETEXILATE; DOUBLE-BLIND; CLINICAL-PRACTICE; STANDARD THERAPY; ENOXAPARIN;

D O I：

10.1183/16000617.0025-2016

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Venous thromboembolism (VTE), consisting of deep vein thrombosis and pulmonary embolism, is a major clinical concern associated with significant morbidity and mortality. The cornerstone of management of VTE is anticoagulation, and traditional anticoagulants include parenteral heparins and oral vitamin K antagonists. Recently, new oral anticoagulant drugs have been developed and licensed, including direct factor Xa inhibitors (e.g. rivaroxaban, apixaban and edoxaban) and thrombin inhibitors (e.g. dabigatran etexilate). This narrative review focusses on the characteristics of these direct anticoagulants and the main results of published clinical studies on their use in the prevention and treatment of VTE.

引用

页码：295 / 302

页数：8

共 60 条

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