Biotransformation enzymes in development of renal injury and urothelial cancer caused by aristolochic acid

被引：66
作者：
Stiborova, M. [1 ]
Frei, E. [2 ]
Schmeiser, H. H. [2 ]
机构：
[1] Charles Univ Prague, Fac Sci, Dept Biochem, Prague 12840 2, Czech Republic
[2] German Canc Res Ctr, Div Mol Toxicol, D-6900 Heidelberg, Germany
来源：
KIDNEY INTERNATIONAL | 2008年 / 73卷 / 11期
关键词：
D O I：
10.1038/ki.2008.125
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Ingestion of aristolochic acid ( AA) is associated with the development of AA-nephropathy and Balkan endemic nephropathy, which are characterized by chronic renal failure, tubulointerstitial fibrosis, and urothelial cancer. Understanding which enzymes are involved in AA activation and/or detoxification is important in assessing susceptibility to AA. Xiao et al. demonstrate that hepatic cytochrome P450s in mice detoxicate AA and thereby protect kidney from injury. The relative contribution of enzymes activating AA to induce urothelial cancer in humans remains to be resolved.
引用
收藏
页码：1209 / 1211
页数：5
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