Heterogeneity in breast cancer

被引：754

作者：

Polyak, Kornelia ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Med Oncol, Dana Farber Canc Inst, Brigham & Womens Hosp,Med Sch, Boston, MA 02215 USA

[2] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 10期

关键词：

TUMOR EVOLUTION; MELANOMA-CELLS; IDENTIFICATION; REARRANGEMENT; LANDSCAPES; CARCINOMAS; PHENOTYPE; LEUKEMIA; FATE;

D O I：

10.1172/JCI60534

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumors as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance. Advances in technologies such as whole-genome sequencing and functional viability screens now allow us to analyze tumors at unprecedented depths. However, translating this increasing knowledge into clinical practice remains a challenge in part due to tumor evolution driven by the diversity of cancer cell populations and their microenvironment. The articles in this Review series discuss recent advances in our understanding of breast tumor heterogeneity, therapies tailored based on this knowledge, and future ways of assessing and treating heterogeneous tumors.

引用

页码：3786 / 3788

页数：3

共 34 条

[31] Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development [J].

Stephens, Philip J. ;

Greenman, Chris D. ;

Fu, Beiyuan ;

Yang, Fengtang ;

Bignell, Graham R. ;

Mudie, Laura J. ;

Pleasance, Erin D. ;

Lau, King Wai ;

Beare, David ;

Stebbings, Lucy A. ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Quail, Michael A. ;

Burton, John ;

Swerdlow, Harold ;

Carter, Nigel P. ;

Morsberger, Laura A. ;

Iacobuzio-Donahue, Christine ;

Follows, George A. ;

Green, Anthony R. ;

Flanagan, Adrienne M. ;

Stratton, Michael R. ;

Futreal, P. Andrew ;

Campbell, Peter J. .

CELL, 2011, 144 (01) :27-40

[32] Complex landscapes of somatic rearrangement in human breast cancer genomes [J].

Stephens, Philip J. ;

McBride, David J. ;

Lin, Meng-Lay ;

Varela, Ignacio ;

Pleasance, Erin D. ;

Simpson, Jared T. ;

Stebbings, Lucy A. ;

Leroy, Catherine ;

Edkins, Sarah ;

Mudie, Laura J. ;

Greenman, Chris D. ;

Jia, Mingming ;

Latimer, Calli ;

Teague, Jon W. ;

Lau, King Wai ;

Burton, John ;

Quail, Michael A. ;

Swerdlow, Harold ;

Churcher, Carol ;

Natrajan, Rachael ;

Sieuwerts, Anieta M. ;

Martens, John W. M. ;

Silver, Daniel P. ;

Langerod, Anita ;

Russnes, Hege E. G. ;

Foekens, John A. ;

Reis-Filho, Jorge S. ;

van't Veer, Laura ;

Richardson, Andrea L. ;

Borresen-Dale, Anne-Lise ;

Campbell, Peter J. ;

Futreal, P. Andrew ;

Stratton, Michael R. .

NATURE, 2009, 462 (7276) :1005-U60

[33] The genomic landscapes of human breast and colorectal cancers [J].

Wood, Laura D. ;

Parsons, D. Williams ;

Jones, Sian ;

Lin, Jimmy ;

Sjoblom, Tobias ;

Leary, Rebecca J. ;

Shen, Dong ;

Boca, Simina M. ;

Barber, Thomas ;

Ptak, Janine ;

Silliman, Natalie ;

Szabo, Steve ;

Dezso, Zoltan ;

Ustyanksky, Vadim ;

Nikolskaya, Tatiana ;

Nikolsky, Yuri ;

Karchin, Rachel ;

Wilson, Paul A. ;

Kaminker, Joshua S. ;

Zhang, Zemin ;

Croshaw, Randal ;

Willis, Joseph ;

Dawson, Dawn ;

Shipitsin, Michail ;

Willson, James K. V. ;

Sukumar, Saraswati ;

Polyak, Kornelia ;

Park, Ben Ho ;

Pethiyagoda, Charit L. ;

Pant, P. V. Krishna ;

Ballinger, Dennis G. ;

Sparks, Andrew B. ;

Hartigan, James ;

Smith, Douglas R. ;

Suh, Erick ;

Papadopoulos, Nickolas ;

Buckhaults, Phillip ;

Markowitz, Sanford D. ;

Parmigiani, Giovanni ;

Kinzler, Kenneth W. ;

Velculescu, Victor E. ;

Vogelstein, Bert .

SCIENCE, 2007, 318 (5853) :1108-1113

[34] Distant metastasis occurs late during the genetic evolution of pancreatic cancer [J].

Yachida, Shinichi ;

Jones, Sian ;

Bozic, Ivana ;

Antal, Tibor ;

Leary, Rebecca ;

Fu, Baojin ;

Kamiyama, Mihoko ;

Hruban, Ralph H. ;

Eshleman, James R. ;

Nowak, Martin A. ;

Velculescu, Victor E. ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Iacobuzio-Donahue, Christine A. .

NATURE, 2010, 467 (7319) :1114-U126

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