Heterogeneity in breast cancer

被引：738

作者：

Polyak, Kornelia ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Med Oncol, Dana Farber Canc Inst, Brigham & Womens Hosp,Med Sch, Boston, MA 02215 USA

[2] Harvard Stem Cell Inst, Cambridge, MA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2011年 / 121卷 / 10期

关键词：

TUMOR EVOLUTION; MELANOMA-CELLS; IDENTIFICATION; REARRANGEMENT; LANDSCAPES; CARCINOMAS; PHENOTYPE; LEUKEMIA; FATE;

D O I：

10.1172/JCI60534

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer is a heterogeneous disease. There is a high degree of diversity between and within tumors as well as among cancer-bearing individuals, and all of these factors together determine the risk of disease progression and therapeutic resistance. Advances in technologies such as whole-genome sequencing and functional viability screens now allow us to analyze tumors at unprecedented depths. However, translating this increasing knowledge into clinical practice remains a challenge in part due to tumor evolution driven by the diversity of cancer cell populations and their microenvironment. The articles in this Review series discuss recent advances in our understanding of breast tumor heterogeneity, therapies tailored based on this knowledge, and future ways of assessing and treating heterogeneous tumors.

引用

页码：3786 / 3788

页数：3

共 34 条

[1] Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M
Wicha, MS
Benito-Hernandez, A
Morrison, SJ
Clarke, MF
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) : 3983 - 3988
[2] Genetic variegation of clonal architecture and propagating cells in leukaemia
Anderson, Kristina
Lutz, Christoph
van Delft, Frederik W.
Bateman, Caroline M.
Guo, Yanping
Colman, Susan M.
Kempski, Helena
Moorman, Anthony V.
Titley, Ian
Swansbury, John
Kearney, Lyndal
Enver, Tariq
Greaves, Mel
[J]. NATURE, 2011, 469 (7330) : 356 - +
[3] A mathematical framework to determine the temporal sequence of somatic genetic events in cancer
Attolini, Camille Stephan-Otto
Cheng, Yu-Kang
Beroukhim, Rameen
Getz, Gad
Abdel-Wahab, Omar
Levine, Ross L.
Mellinghoff, Ingo K.
Michor, Franziska
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (41) : 17604 - 17609
[4] Breast cancer - one term, many entities?
Bertos, Nicholas R.
Park, Morag
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) : 3789 - 3796
[5] Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
Chaffer, Christine L.
Brueckmann, Ines
Scheel, Christina
Kaestli, Alicia J.
Wiggins, Paul A.
Rodrigues, Leonardo O.
Brooks, Mary
Reinhardt, Ferenc
Su, Ying
Polyak, Kornelia
Arendt, Lisa M.
Kuperwasser, Charlotte
Bierie, Brian
Weinberg, Robert A.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (19) : 7950 - 7955
[6] A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS
FEARON, ER
VOGELSTEIN, B
[J]. CELL, 1990, 61 (05) : 759 - 767
[7] Targeted therapies for breast cancer
Higgins, Michaele J.
Baselga, Jose
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) : 3797 - 3803
[8] Comparative lesion sequencing provides insights into tumor evolution
Jones, Sian
Chen, Wei-dong
Parmigiani, Giovanni
Diehl, Frank
Beerenwinkel, Niko
Antal, Tibor
Traulsen, Arne
Nowak, Martin A.
Siegel, Christopher
Velculescu, Victor E.
Kinzler, Kenneth W.
Vogelstein, Bert
Willis, Joseph
Markowitz, Sanford D.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (11) : 4283 - 4288
[9] Breast cancer stem cells, cytokine networks, and the tumor microenvironment
Korkaya, Hasan
Liu, Suling
Wicha, Max S.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (10) : 3804 - 3809
[10] A CELL INITIATING HUMAN ACUTE MYELOID-LEUKEMIA AFTER TRANSPLANTATION INTO SCID MICE
LAPIDOT, T
SIRARD, C
VORMOOR, J
MURDOCH, B
HOANG, T
CACERESCORTES, J
MINDEN, M
PATERSON, B
CALIGIURI, MA
DICK, JE
[J]. NATURE, 1994, 367 (6464) : 645 - 648

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