Cardiovascular Disease in Type 2 Diabetes: A Review of Sex-Related Differences in Predisposition and Prevention

被引：49

作者：

Al-Salameh, Abdallah ^{[1
,2
,3
]}

Chanson, Philippe ^{[2
,4
,5
]}

Bucher, Sophie ^{[1
,6
]}

Ringa, Virginie ^{[1
]}

Becquemont, Laurent ^{[1
,3
,7
]}

机构：

[1] Univ Paris Saclay, Univ Paris Sud, Ctr Rech Epidemiol & Sante Populat CESP, INSERM, Villejuif, France

[2] Hop Bicetre, Hop Univ Paris Sud, AP HP, Serv Endocrinol & Malad Reprod, Le Kremlin Bicetre, France

[3] Hop Bicetre, Hop Univ Paris Sud, AP HP, Ctr Rech Clin Paris Sud, Le Kremlin Bicetre, France

[4] Univ Paris Saclay, Univ Paris Sud, Fac Med, Le Kremlin Bicetre, France

[5] Univ Paris Saclay, Univ Paris Sud, Fac Med, INSERM,U1185, Le Kremlin Bicetre, France

[6] Paris Sud Univ, Fac Med Paris Sud, Dept Gen Practice, Le Kremlin Bicetre, France

[7] Paris Sud Univ, Fac Med Paris Sud, Dept Pharmacol, Le Kremlin Bicetre, France

来源：

MAYO CLINIC PROCEEDINGS | 2019年 / 94卷 / 02期

关键词：

CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; BODY-MASS INDEX; IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE INTERVENTION; RISK-FACTORS; GENDER-DIFFERENCES; LIPID MANAGEMENT; LOWERING THERAPY; DRUG-TREATMENT;

D O I：

10.1016/j.mayocp.2018.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus is a major risk factor for cardiovascular disease. However, compiled data suggest that type 2 diabetes affects the risk of cardiovascular disease differentially according to sex. In recent years, large meta-analyses have confirmed that women with type 2 diabetes have a higher relative risk of incident coronary heart disease, fatal coronary heart disease, and stroke compared with their male counterparts. The reasons for these disparities are not completely elucidated. A greater burden of cardiometabolic risk in women was proposed as a partial explanation. Indeed, several studies suggest that women experience a larger deterioration in major cardiovascular risk factors and put on more weight than do men during their transition from normoglycemia to overt type 2 diabetes. This excess weight is associated with higher levels of biomarkers of endothelial dysfunction, inflammation, and procoagulant state. Moreover, sex differences in the prescription and use of some cardiovascular drugs may compound an "existing" disparity. We searched PubMed for articles published in English and French, by using the following terms: ("cardiovascular diseases") AND ("diabetes mellitus") AND ("sex disparity" OR "sex differences" OR "sex related differences" OR "sex-related differences" OR "sex disparities"). In this article, we review the available literature on the sex aspects of primary and secondary prevention of cardiovascular disease in people with type 2 diabetes, in the predisposition to cardiovascular disease in those people, and in the control of diabetes and associated cardiovascular risk factors. (C) 2018 Mayo Foundation for Medical Education and Research.

引用

页码：287 / 308

页数：22

共 125 条

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