Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement

被引：15

作者：

Rafee, Shereen ^{[1
]}

Elamin, Yasir Y. ^{[1
]}

Joyce, Eimear ^{[1
]}

Toner, Mary ^{[1
]}

Flavin, Richard ^{[1
]}

McDermott, Ronan ^{[1
]}

Sheehy, Niall ^{[1
]}

Hennessy, Bryan ^{[2
]}

O'Byrne, Kenneth ^{[3
]}

Gleeson, Noreen ^{[1
]}

Osman, Nemer ^{[1
]}

机构：

[1] St James Hosp, Dublin 8, Ireland

[2] Beaumont Hosp, Dublin 9, Ireland

[3] Princess Alexandra Hosp, Brisbane, Qld 4102, Australia

来源：

TUMORI | 2015年 / 101卷 / 02期

关键词：

Anaplastic lymphoma kinase (ALK) gene; Crizotinib; Inflammatory myofibroblastic tumour (IMT); SOFT-TISSUE SARCOMAS; LARGE-CELL LYMPHOMA; PSEUDOTUMOR; KINASE; LUNG; DOXORUBICIN; IFOSFAMIDE; EXPRESSION; INHIBITOR; FUSION;

D O I：

10.5301/tj.5000245

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Inflammatory myofibroblastic tumours (IMTs) are rare sarcomas that were first described in the lung. They are composed of myofibroblastic mesenchymal spindle cells accompanied by an inflammatory infiltrate of plasma cells. Complete resection is the treatment of choice. There is currently no standard treatment for inoperable or recurrent disease. Expression of ALK protein triggered by ALK gene rearrangement at chromosome 2p23 has been found in 36%-60% of IMTs. Case report: We report a rapid early response to crizotinib as neoadjuvant therapy, enabling surgical excision of a large ALK-translocated IMT, which resulted in complete disease clearance. To the best of our knowledge, this is the first case in the literature of a patient with IMT in whom crizotinib was used successfully in the neoadjuvant or curative setting.

引用

页码：E35 / E39

页数：5

共 34 条

[1]

[Anonymous], 2011, PATHOLOG RES INT

[2] Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor [J].