GC-MS Chemical Characterization and Antibacterial Effect of the Essential oil of Piper mosenii

被引：1

作者：

de Oliveira Braz, Ana Valeria ^{[1
]}

Rodrigues, Mariana Carvalho ^{[1
]}

Araujo Maia, Philippe Alencar ^{[1
]}

Dantas Pereira, Ana Paula ^{[1
]}

Silva, Jussara de Lima ^{[1
]}

Vieira dos Santos, Francisco Antonio ^{[1
]}

da Silva, Luiz Everson ^{[2
]}

do Amaral, Wanderley ^{[2
]}

dos Santos, Maura Lins ^{[2
]}

Melo Coutinho, Henrique Douglas ^{[3
]}

Baj, Tomasz ^{[4
]}

Kowalska, Grazyna ^{[5
]}

Kowalski, Radoslaw ^{[6
]}

Ferreira Matias, Edinardo Fagner ^{[1
]}

机构：

[1] Fac CECAPE, BR-63024015 Juazeiro Do Norte, Ceara, Brazil

[2] Fed Univ Parana UFPR, Res Lab Nat Prod, BR-80060000 Matinhos, Parana, Brazil

[3] Reg Univ Cariri URCA, Dept Biol Chem, BR-63105010 Crato, Ceara, Brazil

[4] Med Univ Lublin, Dept Pharmacognosy Med Plant Garden, 1 Chodzki Str, PL-20093 Lublin, Poland

[5] Univ Life Sci Lublin, Dept Tourism & Recreat, 15 Akad Str, PL-20950 Lublin, Poland

[6] Univ Life Sci Lublin, Dept Anal & Food Qual Assessment, 8 Skromna Str, PL-20704 Lublin, Poland

来源：

MOLECULES | 2022年 / 27卷 / 18期

关键词：

antibacterial agent; bacterial resistance; oral hygiene; mouthwash; essential oils;

D O I：

10.3390/molecules27185911

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Commercialized mouthwashes are generally expensive for the most financially vulnerable populations. Thus, several studies evaluate the antimicrobial potential of herbal products, such as essential oils, to reduce the activity of microorganisms in the mouth. The objective of this research was to carry out the chemical characterization and antibacterial activity of the essential oil of Piper mosenii (EOPm), providing data that enable the development of a low-cost mouthwash formulation aimed at vulnerable communities. The analysis of the antibacterial potential and modulator of bacterial resistance was verified by the microdilution method to determine the minimum inhibitory concentration-MIC. The chemical components were characterized by gas chromatography coupled to mass spectrometry, where 23 chemical constituents were detected, with alpha-pinene, being the major compound. The EOPm showed a MIC >= 1024 mu g/mL for all bacterial strains used in the tests. When the EOPm modulating activity was evaluated together with chlorhexidine, mouthwash and antibiotics against bacterial resistance, the oil showed a significant synergistic effect, reducing the MIC of the products tested in combination, in percentages between 20.6% to 96.3%. Therefore, it is recommended to expand the tests with greater variation of EOPm concentration and the products used in this research, in addition to the evaluation of toxicity and in vivo tests, seeking the development of a possible formulation of mouthwash accessible to the vulnerable population.

引用

页数：11

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