Reversal of bone marrow fibrosis in idiopathic myelofibrosis after treatment with α-interferon

被引:0
作者
Domingues, MA
Hæpers, ATC
Massaut, IHB
Vassallo, J
Lorand-Metze, I
机构
[1] State Univ Campinas, Fac Med, Campinas, SP, Brazil
[2] Hematol Hemotherapy Ctr Florianopolis, Florianopolis, SC, Brazil
关键词
myelofibrosis; children; interferon; treatment;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A 14-year-old boy presenting with primary myelofibrosis (MMM) was treated with alpha-interferon (IFN). After 6 months his spleen was no longer palpable and blood counts had returned to normal. A reversal of bone marrow fibrosis was histologically documented. Although improvement in symptoms and blood counts has been reported, this is only the second description of reversal of bone marrow fibrosis in MMM after treatment.
引用
收藏
页码:1124 / 1125
页数:2
相关论文
共 50 条
  • [1] A SEQUENTIAL HISTOLOGICAL STUDY OF BONE-MARROW FIBROSIS IN IDIOPATHIC MYELOFIBROSIS
    HASSELBALCH, H
    LISSE, I
    EUROPEAN JOURNAL OF HAEMATOLOGY, 1991, 46 (05) : 285 - 289
  • [2] The role of interferon-α in the treatment of idiopathic myelofibrosis
    Bachleitner-Hofmann, T
    Gisslinger, H
    ANNALS OF HEMATOLOGY, 1999, 78 (12) : 533 - 538
  • [3] The role of interferon-α in the treatment of idiopathic myelofibrosis
    T. Bachleitner-Hofmann
    H. Gisslinger
    Annals of Hematology, 1999, 78 : 533 - 538
  • [4] Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly
    Berrebi, A.
    Feldberg, E.
    Spivak, I
    Shvidel, L.
    HAEMATOLOGICA, 2007, 92 (02) : 15 - 16
  • [5] Bone marrow histopathology following cytoreductive therapy in chronic idiopathic myelofibrosis
    Thiele, J
    Kvasnicka, HM
    Schmitt-Graeff, A
    Diehl, V
    HISTOPATHOLOGY, 2003, 43 (05) : 470 - 479
  • [6] Therapy-related changes of the bone marrow in chronic idiopathic myelofibrosis
    Thiele, J
    Kvasnicka, HM
    Schmitt-Gräff, A
    Hülsemann, R
    Diehl, V
    HISTOLOGY AND HISTOPATHOLOGY, 2004, 19 (01) : 239 - 250
  • [7] Idiopathic myelofibrosis: pathogenesis to treatment
    Reilly, John T.
    HEMATOLOGICAL ONCOLOGY, 2006, 24 (02) : 56 - 63
  • [8] Grade of bone marrow fibrosis is associated with relevant hematological findings - a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis
    Thiele, J
    Kvasnicka, HM
    ANNALS OF HEMATOLOGY, 2006, 85 (04) : 226 - 232
  • [9] Grade of bone marrow fibrosis is associated with relevant hematological findings—a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis
    J. Thiele
    H. M. Kvasnicka
    Annals of Hematology, 2006, 85 : 226 - 232
  • [10] Dynamic of Bone Marrow Fibrosis Regression Predicts Survival after Allogeneic Stem Cell Transplantation for Myelofibrosis
    Kroeger, Nicolaus
    Zabelina, Tatjana
    Alchalby, Haefaa
    Stuebig, Thomas
    Wolschke, Christine
    Ayuk, Francis
    von Huenerbein, Natascha
    Kvasnicka, Hans-Michael
    Thiele, Juergen
    Kreipe, Hans-Heinrich
    Buesche, Guntram
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (06) : 812 - 815