Correlation between reduction potentials and inhibitory effects on Epstein-Barr virus activation of poly-substituted anthraquinones

被引：10

作者：

Koyama, J ^{[1
]}

Morita, I

Kobayashi, N

Osakai, T

Nishino, H

Tokuda, H

机构：

[1] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6588558, Japan

[2] Kobe Univ, Fac Sci, Dept Chem, Kobe, Hyogo 6578501, Japan

[3] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kyoto 6028566, Japan

来源：

CANCER LETTERS | 2005年 / 225卷 / 02期

关键词：

Epstein-Barr virus; anthraquinone; reduction potential; cyclic voltammetry;

D O I：

10.1016/j.canlet.2004.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction potentials of some poly-substituted anthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the reduction potentials and the inhibitory effects of the poly-substituted anthraquinones on Epstein-Barr virus early antigen activation. It has been further shown that the correlation can be enhanced by introducing log P as an additional parameter. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：193 / 198

页数：6

共 17 条

[1] ATOMIC PHYSICOCHEMICAL PARAMETERS FOR 3-DIMENSIONAL STRUCTURE DIRECTED QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .3. MODELING HYDROPHOBIC INTERACTIONS [J].

GHOSE, AK ;

PRITCHETT, A ;

CRIPPEN, GM .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (01) :80-90

[2] IMMUNOFLUORESCENCE IN CELLS DERIVED FROM BURKITTS LYMPHOMA [J].

HENLE, G ;

HENLE, W .

JOURNAL OF BACTERIOLOGY, 1966, 91 (03) :1248-&

[3] A SHORT-TERM INVITRO ASSAY FOR PROMOTER SUBSTANCES USING HUMAN-LYMPHOBLASTOID CELLS LATENTLY INFECTED WITH EPSTEIN-BARR VIRUS [J].

ITO, Y ;

YANASE, S ;

FUJITA, J ;

HARAYAMA, T ;

TAKASHIMA, M ;

IMANAKA, H .

CANCER LETTERS, 1981, 13 (01) :29-37

[4] Anti-tumor promoting effects of naphthoquinone derivatives on short term Epstein-Barr early antigen activation assay and in mouse skin carcinogenesis [J].

Kapadia, GJ ;

Balasubramanian, V ;

Tokuda, H ;

Konoshima, T ;

Takasaki, M ;

Koyama, J ;

Tagahaya, K ;

Nishino, H .

CANCER LETTERS, 1997, 113 (1-2) :47-53

[5] STUDIES ON INHIBITORS OF SKIN TUMOR PROMOTION .6. INHIBITORY EFFECTS OF QUINONES ON EPSTEIN-BARR VIRUS-ACTIVATION [J].

KONOSHIMA, T ;

KOZUKA, M ;

KOYAMA, J ;

OKATANI, T ;

TAGAHARA, K ;

TOKUDA, H .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (05) :987-995

[6] NAPHTHO[2,3-C]FURAN-4,9-DIONE AND ITS DERIVATIVES FROM ALOE FEROX [J].

KOYAMA, J ;

OGURA, T ;

TAGAHARA, K .

PHYTOCHEMISTRY, 1994, 37 (04) :1147-1148

[7] Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones [J].

Koyama, J ;

Morita, I ;

Kobayashi, N ;

Osakai, T ;

Hotta, H ;

Takayasu, J ;

Nishino, H ;

Tokuda, H .

CANCER LETTERS, 2004, 212 (01) :1-6

[8] Correlation of redox potentials and inhibitory effects on Epstein-Baff virus activation of naphthoquinones [J].

Koyama, J ;

Morita, I ;

Kobayashi, N ;

Osakai, T ;

Hotta, H ;

Takayasu, J ;

Nishino, H ;

Tokuda, H .

CANCER LETTERS, 2003, 201 (01) :25-30

[9] Correlation with redox potentials and inhibitory effects on Epstein-Barr virus activation of azaanthraquinones [J].

Koyama, J ;

Morita, I ;

Tagahara, K ;

Osakai, T ;

Hotta, H ;

Yang, MX ;

Mukainaka, T ;

Nishino, H ;

Tokuda, H .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2001, 49 (09) :1214-1216

[10] Inhibitory effects on Epstein-Barr virus activation of anthraquinones: Correlation with redox potentials [J].

Koyama, J ;

Tagahara, K ;

Osakai, T ;

Tsujino, Y ;

Tsurumi, S ;

Nishino, H ;

Tokuda, H .

CANCER LETTERS, 1997, 115 (02) :179-183

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