MicroRNAs in vertebrate development

被引：313

作者：

Harfe, BD ^{[1
]}

机构：

[1] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2005年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.gde.2005.06.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The vertebrate genome contains hundreds of small non-coding 'microRNAs' that have been implicated in controlling the expression of potentially thousands of target genes. Presently, only a handful of these targets have been characterized. Recent reports of microRNA 'sensors', microRNA microarrays and the creation of vertebrates that lack all microRNA activity will aid in determining the roles played by microRNAs, and the genes that they regulate, during vertebrate development.

引用

页码：410 / 415

页数：6

共 45 条

[1] Probing microRNAs with microarrays: Tissue specificity and functional inference [J].

Babak, T ;

Zhang, W ;

Morris, Q ;

Blencowe, BJ ;

Hughes, TR .

RNA, 2004, 10 (11) :1813-1819

[2] MicroRNA expression detected by oligonucleotide microarrays: System establishment and expression profiling in human tissues [J].

Barad, O ;

Meiri, E ;

Avniel, A ;

Aharonov, R ;

Barzilai, A ;

Bentwich, I ;

Einav, U ;

Glad, S ;

Hurban, P ;

Karov, Y ;

Lobenhofer, EK ;

Sharon, E ;

Shiboleth, YM ;

Shtutman, M ;

Bentwich, Z ;

Einat, P .

GENOME RESEARCH, 2004, 14 (12) :2486-2494

[3] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[4] Dicer is essential for mouse development [J].

Bernstein, E ;

Kim, SY ;

Carmell, MA ;

Murchison, EP ;

Alcorn, H ;

Li, MZ ;

Mills, AA ;

Elledge, SJ ;

Anderson, KV ;

Hannon, GJ .

NATURE GENETICS, 2003, 35 (03) :215-217

[5] bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila [J].

Brennecke, J ;

Hipfner, DR ;

Stark, A ;

Russell, RB ;

Cohen, SM .

CELL, 2003, 113 (01) :25-36

[6] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[7] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[8] MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias [J].

Calin, GA ;

Liu, CG ;

Sevignani, C ;

Ferracin, M ;

Felli, N ;

Dumitru, CD ;

Shimizu, M ;

Cimmino, A ;

Zupo, S ;

Dono, M ;

Dell'Aquila, ML ;

Alder, H ;

Rassenti, L ;

Kipps, TJ ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (32) :11755-11760

[9] RNase III enzymes and the initiation of gene silencing [J].

Carmell, MA ;

Hannon, GJ .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (03) :214-218

[10] MicroRNAs modulate hematopoietic lineage differentiation [J].

Chen, CZ ;

Li, L ;

Lodish, HF ;

Bartel, DP .

SCIENCE, 2004, 303 (5654) :83-86

← 1 2 3 4 5 →