Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry

被引：30

作者：

Del Zotto, Genny ^{[1
,2
]}

Antonini, Francesca ^{[1
,2
]}

Pesce, Silvia ^{[3
]}

Moretta, Francesca ^{[4
]}

Moretta, Lorenzo ^{[5
]}

Marcenaro, Emanuela ^{[3
,6
]}

机构：

[1] IRCCS Ist G Gaslini, Area Aggregaz Serv, Core Facil, Genoa, Italy

[2] IRCCS Ist G Gaslini, Lab Diagnostici, Genoa, Italy

[3] Univ Genoa, Dept Expt Med, Genoa, Italy

[4] IRCCS Sacro Cuore Don Calabria Hosp, Dept Lab Med, Negrar, Italy

[5] IRCCS Bambino Gesu Childrens Hosp, Dept Immunol, Rome, Italy

[6] Univ Genoa, Ctr Excellence Biomed Res, Genoa, Italy

来源：

CYTOMETRY PART A | 2020年 / 97卷 / 09期

关键词：

flow cytometry; human NK cells; phenotyping; NK cell subsets; NATURAL-KILLER-CELLS; POLYMORPHIC HLA-B; CLASS-I MOLECULES; DENDRITIC CELLS; MEDIATED CYTOTOXICITY; FAS-LIGAND; T-CELL; FUNCTIONAL-HETEROGENEITY; NTB-A; RECEPTORS;

D O I：

10.1002/cyto.a.24001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The NK cell compartment provides powerful innate defenses against virus-infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different functional capabilities exist and this reflects not only the different maturation stages of NK cells but also different microenvironments in which they can operate. In this review, we will give an overview on the various NK cell subsets present in peripheral blood of healthy donors in order to clearly and univocally identify them on the basis of their phenotypic traits using flow cytometry. (c) 2020 International Society for Advancement of Cytometry

引用

页码：891 / 899

页数：9

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