Assessment of Reactive Metabolites in Drug-Induced Liver Injury

被引：11

作者：

Lee, Kye Sook ^{[1
]}

Oh, Soo Jin ^{[2
]}

Kim, Hwan Mook ^{[3
]}

Lee, Ki Ho ^{[4
]}

Kim, Sang Kyum ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] KRIBB, Bioevaluat Ctr, Ochang 305806, Chungbuk, South Korea

[3] Gachon Univ Med & Sci, Dept Pharm, Coll Pharm, Inchon 406799, South Korea

[4] Korea Univ, Dept Pharm, Coll Pharm, Chungnam 339700, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 11期

关键词：

Acyl glucuronide; Drug-induced liver injury; Drug metabolism; Mechanism-based inhibition; Reactive metabolites; HUMAN SERUM-ALBUMIN; DIFLUNISAL ACYL GLUCURONIDE; COVALENT BINDING; IN-VITRO; MECHANISMS; TOXICITY; IDENTIFICATION; DISPOSITION; TOXICOLOGY; CYTOCHROME-P450;

D O I：

10.1007/s12272-011-1108-x

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The aim of the current review is to summarize present methods used for the determination of reactive metabolites, which can predict drug-induced liver injury (DILI) in drug discovery and development. DILI is one of the most frequent reasons for the withdrawal of an approved drug from the market, and it accounts for up to 50% of acute liver failure cases. This review is structured into three sections. The first section is a general overview of the relationship between drug metabolism and liver injury. The second section introduces in vitro methods for the assessment of reactive metabolites for drug discovery and development. In the third section, limitations and future directions for the development of methods for predicting DILI are described.

引用

页码：1879 / 1886

页数：8

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