Medicinal Attributes of Imidazo[1,2-a] pyridine Derivatives: An Update

被引：114

作者：

Devi, Nisha ^{[1
]}

Singh, Dharmender ^{[1
]}

Rawal, Ravindra K. ^{[2
]}

Bariwal, Jitender ^{[2
,3
]}

Singh, Virender ^{[1
]}

机构：

[1] Dr BR Ambedkar Natl Inst Technol, Dept Chem, Jalandhar 144011, India

[2] Indo Soviet Friendship Coll Pharm, Dept Pharmaceut Chem, Moga 142001, Punjab, India

[3] Satiate Res & Anatech Pvt Ltd, Panchkula 134102, Haryana, India

来源：

CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2016年 / 16卷 / 26期

关键词：

Imidazo[1,2-a] pyridine; SAR; Groebke-Blackburn-Bienayme reaction; Ugi Type; Multicomponent Reaction; N-fused imidazole; PERIPHERAL BENZODIAZEPINE-RECEPTOR; ONE-POT SYNTHESIS; IMIDAZOPYRIDINE ANTICOCCIDIAL AGENTS; BIOLOGICAL EVALUATION; SELECTIVE LIGANDS; BINDING-AFFINITY; ANTIULCER AGENTS; MULTICOMPONENT REACTIONS; POTENTIAL INHIBITORS; FACILE SYNTHESIS;

D O I：

10.2174/1568026616666160506145539

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The imidazo[1,2-a] pyridine scaffold is recognized as a privileged structure as it represents a promising area for identification of lead structures towards the discovery of new synthetic drug molecules. Several commercial drugs such as Zolpidem, Olprinone, Soraprazan and many other compounds in biological testing and preclinical evaluation, illustrate the wide therapeutic spectrum in this class of drug scaffolds. The present manuscript represents the assimilation of literature pertaining to medicinal aspects of this pharmacophore including the structure-activity relationships.

引用

页码：2963 / 2994

页数：32

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