A new steroidal saponin from Allium ampeloprasum var. porrum with antiinflammatory and gastroprotective effects

被引：17

作者：

Adao, Camila Rodrigues ^{[1
]}

da Silva, Bernadete Pereira ^{[1
]}

Parente, Jose Paz ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Nucleo Pesquisas Prod Nat, Lab Quim Plantas Med, BR-21941971 Rio De Janeiro, Brazil

来源：

PHYTOCHEMISTRY LETTERS | 2011年 / 4卷 / 03期

关键词：

Allium ampeloprasum var. porrum; Alliaceae; Steroidal saponin; Antiinflammatory activity; Gastroprotective effect; GAS-LIQUID CHROMATOGRAPHY; MONOSACCHARIDES; SAPOGENINS;

D O I：

10.1016/j.phytol.2011.05.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new steroidal saponin was isolated from the bulbs of Allium ampeloprasum var. porrum. On the basis of chemical conversions and detailed analyses of (1)H and (13)C NMR spectra including 2D NMR spectroscopic techniques, its structure was established as 3-[(O-beta-D-glucopyranosyl-(1 -> 3)-beta-D-glucopyranosyl-(1 -> 2)-O-[O-beta-D-glucopyranosyl-(1 -> 3)]-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-galactopyranosyl)oxy]2,6-dihydroxy-(2 alpha,3 beta,5 alpha,6 beta,25R)-spirostane. Results of the present study indicated that the steroidal saponin showed haemolytic effects in the in vitro assays and demonstrated antiinflammatory activity and gastroprotective property using in vivo models. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

引用

页码：306 / 310

页数：5

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