A green route to water-soluble polyaniline for photothermal therapy catalyzed by iron phosphates peroxidase mimic

被引：25

作者：

Li, Leilei ^{[1
]}

Liang, Kaixuan ^{[1
]}

Hua, Zhentao ^{[1
]}

Zou, Min ^{[2
]}

Chen, Kezheng ^{[1
]}

Wang, Wei ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Mat Sci & Engn, Lab Funct & Biomed Nanomat, Qingdao 266042, Peoples R China

[2] Yebio Bioengn Co Ltd, Qingdao 266032, Peoples R China

来源：

POLYMER CHEMISTRY | 2015年 / 6卷 / 12期

关键词：

CANCER-CELLS; CONVERSION EFFICIENCY; POLYPYRROLE NANOPARTICLES; CONDUCTING POLYANILINE; GOLD NANOPARTICLES; CARBON NANOTUBES; ABLATION; AGENT; BIOCATALYSIS; NANOCRYSTALS;

D O I：

10.1039/c4py01716a

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A green route to water-soluble polyaniline (PANI) using iron phosphates (FePOs) peroxidase mimic as a catalyst and H2O2 as an oxidant is presented. Polystyrene sulfonate (PSS) is used as a template to synthesize a conductive PANI-PSS complex. PANI samples were characterized by UV-Vis spectroscopy, FT-IR spectroscopy and bulk conductivity measurement. Results indicated that the conductivity of the PANI catalyzed by the FePOs peroxidase mimic greatly depends on the pH, temperature and molar ratios of H2O2 and aniline. Superior to natural horseradish peroxidase, the prepared FePOs demonstrated a robust catalytic ability and could catalyze the formation of PANI-PSS at much lower pH values of 1.5-2.6. The photothermal effect of the FePOs catalyzed PANI samples was investigated and a high light-to-heat conversion efficiency of 39.6% was obtained for the sample with a conductivity of 2.576 x 10(-3) S cm(-1). Excellent biocompatibility and remarkable anti-tumor effect were observed for the prepared PANI with human cervical cancer (HeLa) cells as a cell model.

引用

页码：2290 / 2296

页数：7

共 46 条

[1] Near-infrared light-triggered irreversible aggregation of poly(oligo(ethylene glycol) methacrylate)-stabilised polypyrrole nanoparticles under biologically relevant conditions [J].

Au, Kin Man ;

Chen, Mei ;

Armes, Steven P. ;

Zheng, Nanfeng .

CHEMICAL COMMUNICATIONS, 2013, 49 (89) :10525-10527

[2] POLARONS AND BIPOLARONS IN POLYPYRROLE - EVOLUTION OF THE BAND-STRUCTURE AND OPTICAL-SPECTRUM UPON DOPING [J].

BREDAS, JL ;

SCOTT, JC ;

YAKUSHI, K ;

STREET, GB .

PHYSICAL REVIEW B, 1984, 30 (02) :1023-1025

[3] POLARONS, BIPOLARONS, AND SOLITONS IN CONDUCTING POLYMERS [J].

BREDAS, JL ;

STREET, GB .

ACCOUNTS OF CHEMICAL RESEARCH, 1985, 18 (10) :309-315

[4] Tumor Regression In Vivo by Photothermal Therapy Based on Gold-Nanorod-Loaded, Functional Nanocarriers [J].

Choi, Won Il ;

Kim, Ja-Young ;

Kang, Chul ;

Byeon, Clare C. ;

Kim, Young Ha ;

Tee, Giyoong .

ACS NANO, 2011, 5 (03) :1995-2003

[5] Helical Carbon Nanotubes: Intrinsic Peroxidase Catalytic Activity and Its Application for Biocatalysis and Biosensing [J].

Cui, Rongjing ;

Han, Zhida ;

Zhu, Jun-Jie .

CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (34) :9377-9384

[6] STERIC AND ELECTRONIC EFFECTS IN METHYL AND METHOXY SUBSTITUTED POLYANILINES [J].

DAPRANO, G ;

LECLERC, M ;

ZOTTI, G .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1993, 351 (1-2) :145-158

[7] VIBRATIONAL-SPECTRA AND STRUCTURE OF POLYANILINE [J].

FURUKAWA, Y ;

UEDA, F ;

HYODO, Y ;

HARADA, I ;

NAKAJIMA, T ;

KAWAGOE, T .

MACROMOLECULES, 1988, 21 (05) :1297-1305

[8] Intrinsic peroxidase-like activity of ferromagnetic nanoparticles [J].

Gao, Lizeng ;

Zhuang, Jie ;

Nie, Leng ;

Zhang, Jinbin ;

Zhang, Yu ;

Gu, Ning ;

Wang, Taihong ;

Feng, Jing ;

Yang, Dongling ;

Perrett, Sarah ;

Yan, Xiyun .

NATURE NANOTECHNOLOGY, 2007, 2 (09) :577-583

[9]

Heeger AJ, 2001, ANGEW CHEM INT EDIT, V40, P2591, DOI 10.1002/1521-3773(20010716)40:14<2591::AID-ANIE2591>3.0.CO

[10]

2-0

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