Multimodal functional and structural neuroimaging investigation of major depressive disorder following treatment with duloxetine

被引:71
作者
Fu, Cynthia H. Y. [1 ,2 ]
Costafreda, Sergi G. [3 ,4 ]
Sankar, Anjali [2 ]
Adams, Tracey M. [5 ]
Rasenick, Mark M. [6 ,7 ]
Liu, Peng [8 ]
Donati, Robert [6 ,9 ]
Maglanoc, Luigi A. [10 ]
Horton, Paul [4 ]
Marangell, Lauren B. [11 ]
机构
[1] Univ E London, Sch Psychol, London E15 4LZ, England
[2] Kings Coll London, Ctr Affect Disorders, IoPPN, London, England
[3] UCL, Dept Psychiat, London, England
[4] Kings Coll London, IoPPN, Dept Old Age Psychiat, London, England
[5] Warneford Hosp, Psychol Serv, Oxford OX3 7JX, England
[6] Univ Illinois, Coll Med, Chicago, IL USA
[7] Jesse Brown VA Med Ctr, Chicago, IL USA
[8] Eli Lilly & Co, Indianapolis, IN 46285 USA
[9] Illinois Coll Optometry, Chicago, IL USA
[10] UCL, Inst Neurol, Dept Neurodegenerat Dis, London, England
[11] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
关键词
Antidepressant; BOLD; Brain; Function; Prognosis; Predictor; Structure; ANTIDEPRESSANT TREATMENT; DEFAULT MODE; FACIAL EXPRESSIONS; AMYGDALA RESPONSES; NEURAL RESPONSES; RATING-SCALE; MOOD STATE; METAANALYSIS; CONNECTIVITY; FACES;
D O I
10.1186/s12888-015-0457-2
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Longitudinal neuroimaging studies of major depressive disorder (MDD) have most commonly assessed the effects of antidepressants from the serotonin reuptake inhibitor class and usually reporting a single measure. Multimodal neuroimaging assessments were acquired from MDD patients during an acute depressive episode with serial measures during a 12-week treatment with the serotonin-norepinephrine reuptake inhibitor (SNRI) duloxetine. Methods: Participants were medication-free MDD patients (n = 32; mean age 40.2 years) in an acute depressive episode and healthy controls matched for age, gender, and IQ (n = 25; mean age 38.8 years). MDD patients received treatment with duloxetine 60 mg daily for 12 weeks with an optional dose increase to 120 mg daily after 8 weeks. All participants had serial imaging at weeks 0, 1, 8, and 12 on a 3 Tesla magnetic resonance imaging (MRI) scanner. Neuroimaging tasks included emotional facial processing, negative attentional bias (emotional Stroop), resting state functional MRI and structural MRI. Results: A significant group by time interaction was identified in the anterior default mode network in which MDD patients showed increased connectivity with treatment, while there were no significant changes in healthy participants. In the emotional Stroop task, increased posterior cingulate activation in MDD patients normalized following treatment. No significant group by time effects were observed for happy or sad facial processing, including in amygdala responsiveness, or in regional cerebral volumes. Reduced baseline resting state connectivity within the orbitofrontal component of the default mode network was predictive of clinical response. An early increase in hippocampal volume was predictive of clinical response. Conclusions: Baseline resting state functional connectivity was predictive of subsequent clinical response. Complementary effects of treatment were observed from the functional neuroimaging correlates of affective facial expressions, negative attentional bias, and resting state. No significant effects were observed in affective facial processing, while the interaction effect in negative attentional bias and individual group effects in resting state connectivity could be related to the SNRI class of antidepressant medication. The specificity of the observed effects to SNRI pharmacological treatments requires further investigation.
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页数:11
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