New tetrahydroisoquinolinones from Hyeronima oblonga (Euphorbiaceae)

被引：8

作者：

Alves, TMA ^{[1
]}

Zani, CL ^{[1
]}

机构：

[1] Minist Saude, Ctr Pesquisas Rene Rachou, Lab Quim Prod Naturais, Fiocruz MS, BR-30190002 Belo Horizonte, MG, Brazil

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(98)02276-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The bioassay-guided fractionation of the CH2Cl2 extract from the wood of Hyeronima oblonga (Euphorbiaceae) afforded two new alkaloids with a tetrahydroisoquinolinone nucleus described here for the first time. The compounds 3-methyl-4-methoxy-6-(1-oxoctyl.)-5,6,7,8-tetrahydro-1(2H) isoquinolinone (Hyeronine A, 4a) and 3-methyl-4-methoxy-6-(1-oxohexyl)-5,6, 7,8-tetrahydro-1(2H)isoquinolinone (Hyeronine B, 4b) displayed LC50 of 4 ppm in the brine shrimp lethality assay. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：205 / 208

页数：4

共 6 条

[1]

DEWICK PM, 1997, MED NATURAL PRODUCTS, P298

[2] RETRO-ENE REACTIONS IN HETEROCYCLIC SYNTHESIS .2. A FACILE SYNTHETIC METHOD FOR 4-HYDROXY-2-PYRIDONES [J].