Ghrelin and cancer

被引：61
作者：
Chopin, Lisa [1 ]
Walpole, Carina [1 ]
Seim, Inge [1 ]
Cunningham, Peter [1 ]
Murray, Rachael [1 ]
Whiteside, Eliza [1 ]
Josh, Peter [1 ,2 ]
Herington, Adrian [1 ]
机构：
[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Ghrelin Res Grp, Brisbane, Qld 4001, Australia
[2] Commonwealth Sci & Ind Res Org, Brisbane, Qld, Australia
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 340卷 / 01期
基金：
英国医学研究理事会;
关键词：
Ghrelin; Growth hormone secretagogue receptor; Cancer; Proliferation; Apoptosis; Cell migration and invasion; HORMONE SECRETAGOGUE RECEPTOR; DES-ACYL GHRELIN; MESSENGER-RNA EXPRESSION; ACTIVATED PROTEIN-KINASE; HUMAN PITUITARY-TUMORS; CELL-LINES; INHIBITS APOPTOSIS; ENDOCRINE TUMORS; PROSTATE-CANCER; IN-VITRO;
D O I：
10.1016/j.mce.2011.04.013
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular and immune systems. Ghrelin and its receptor are expressed in a number of cancers and cancer cell lines and may play a role in processes associated with cancer progression, including cell proliferation, apoptosis, and cell invasion and migration. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：65 / 69
页数：5
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