Hydroxytyrosol: A natural compound with promising pharmacological activities

被引：183

作者：

Bertelli, Matteo ^{[1
,3
,4
]}

Kiani, Aysha Karim ^{[2
]}

Paolacci, Stefano ^{[3
]}

Manara, Elena ^{[4
]}

Kurti, Danjela ^{[5
]}

Dhuli, Kristjana ^{[5
]}

Bushati, Vilma ^{[5
]}

Miertus, Jan ^{[6
]}

Pangallo, Domenico ^{[7
]}

Baglivo, Mirko ^{[4
]}

Beccari, Tommaso ^{[8
]}

Michelini, Sandro ^{[9
]}

机构：

[1] EBTNA Lab, Via Maiol 57-G, I-38068 Rovereto, TN, Italy

[2] Allama Iqbal Open Univ, Sect H-8, Islamabad 44000, Pakistan

[3] MAGIs Lab, Via Maiol 57-D, I-38068 Rovereto, TN, Italy

[4] MAGI Euregio, Via Maso Pieve 60-A, I-39100 Bolzano, Italy

[5] MAGI Balkans, Rruga Andon Zako Cajupi, Tirana 1019, Albania

[6] Genius No, Mestska Poliklin Starohajska 2, Trnava 91701, Slovakia

[7] Slovak Acad Sci, Inst Mol Biol, Dubravska Cesta 21, Bratislava 84551, Slovakia

[8] Univ Perugia, Dept Pharmaceut Sci, Via Ariodante Fabretti 48, I-06123 Perugia, Italy

[9] San Giovanni Battista Hosp, Dept Vasc Rehabil, Via Luigi Ercole Morselli 13, I-00148 Rome, Italy

来源：

JOURNAL OF BIOTECHNOLOGY | 2020年 / 309卷

关键词：

Pharmacological activity; Molecular pathways; Hydroxytyrosol; VIRGIN OLIVE OIL; VASCULAR ENDOTHELIAL-CELLS; PHENOLIC-COMPOUNDS; OXIDATIVE INJURY; NRF2; ACTIVATION; CYCLE ARREST; OLEUROPEIN; PROLIFERATION; APOPTOSIS; POLYPHENOLS;

D O I：

10.1016/j.jbiotec.2019.12.016

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Hydroxytyrosol is a phenolic phytochemical with antioxidant properties in vitro. It is a natural compound that can be found in olive leaves and oil. The main dietary source of hydroxytyrosol is extra virgin olive oil. Due to its bioavailability, chemical properties and easy formulation along with its lack of toxicity, hydroxytyrosol is considered an excellent food supplement by the nutraceutical and food industries. The purpose of this review is to discuss the potential therapeutic effects of hydroxytyrosol in vivo. To do so, we conducted an electronic search in PubMed and other literature databases using "hydroxytyrosol", "beneficial effect/s", "pharmacology" as keywords. From this search, we found that hydroxytyrosol has anti-inflammatory, anti-tumor, antiviral, antibacterial and antifungal properties. Hydroxytyrosol also improves endothelial dysfunction, decreases oxidative stress, and is neuro- and cardio-protective. Due to all these biological properties, hydroxytyrosol is currently the most actively investigated natural phenol. The evidence presented in this review suggests that hydroxytyrosol has great pharmacological potential.

引用

页码：29 / 33

页数：5

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