Synthesis and antimicrobial activity of new N-[4-(4-hydroxy-2-oxo-2H-chromen-3-yl)thiazol-2-yl]benzenesulfonamides

New N-[4-(4-hydroxy-2-oxo-2H-chromen-3-yl)thiazol-2-yl]benzenesulfonamides were synthesized and their antimicrobial activity was tested in relation to some bacteria and fungi. Through the reaction of bromination with phenyltrimethylammonium tribromide, 3-acetyl-4-hydroxy-2H-chromen-2-one yields 3-bromoacetyl-4-hydroxy-2H-chromen-2-one which through reaction with thiourea gives 3-(2-aminothiazol-4-yl)-4-hydroxy-2H-chromen-2-one (III) in the form of a bromide salt. Compound III was the starting substrate in condensation reactions with corresponding arenesulfonyl chlorides yielding the required derivatives. Chemical structure of the obtained compounds was confirmed by elemental and structural analysis (IR, H-1 and C-13 NMR). Also, the disk diffusion method was used to test the inhibitory activity of four of the new sulfonamides in relation to twelve microorganisms.