The Cellular Mechanisms of Dopamine Modulation on the Neuronal Network Oscillations in the CA3 Area of Rat Hippocampal Slices

被引：4

作者：

Xie, Xin'e ^{[1
,3
]}

Li, Mingcan ^{[1
,2
]}

Feng, Bingyan ^{[1
]}

Li, Junmei ^{[1
]}

Sun, Zhongyu ^{[1
]}

Zhao, Ying ^{[2
]}

Lu, Chengbiao ^{[1
]}

机构：

[1] Xinxiang Med Univ, Dept Physiol, Key Lab Brain Res Henan Prov, Henan Int Joint Lab Noninvas Neural Modulat, Xinxiang 453003, Henan, Peoples R China

[2] Xinxiang Med Univ, Sch Pharm, Key Lab Clin Psychopharmacol, Xinxiang 453003, Henan, Peoples R China

[3] Second Hosp Jinhua, Jinhua 321000, Zhejiang, Peoples R China

来源：

NEUROSCIENCE | 2021年 / 475卷

基金：

中国国家自然科学基金;

关键词：

RTK; ERK; PKA; dopamine; y oscillations; GAMMA OSCILLATIONS; SIGNALING PATHWAY; KINASE; INHIBITION; EXPRESSION; NEUREGULIN; RECEPTORS; ATTENTION; CORTEX; PI3K;

D O I：

10.1016/j.neuroscience.2021.09.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Network oscillations at y frequency band (30-80 Hz), generated by the interaction between inhibitory interneurons and excitatory neurons, have been proposed to be associated with higher brain functions such as learning and memory. Dopamine (DA), one of the major CNS transmitters, modulates hippocampal y oscillations but the intracellular mechanisms involved remain elusive. In this study, we recorded kainate-induced y oscillations in the CA3 area of rat hippocampal slices, and found that DA strongly enhanced y power, which was largely blocked by dopamine receptor 1 (DR1) antagonist SCH23390, receptor tyrosine kinase (RTK) inhibitor UNC569 and ERK inhibitor U0126, partially blocked by D2/3R antagonist raclopride, PKA inhibitor H89 and PI3K inhibitor wortmannin, but not affected by AKT inhibitor TCBN or NMDAR antagonist D-AP5. Our results indicate that DA-mediated y enhancement is involved in the activation of signaling pathway of DR1/2-RTK-ERK. Our data demonstrate a strong, rapid modulation of DA on hippocampal y oscillations and provide a new insight into cellular mechanisms of DA-mediated y oscillations. (c) 2021 Published by Elsevier Ltd on behalf of IBRO.

引用

页码：83 / 92

页数：10

共 42 条

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