Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection

被引：9

作者：

Kali, Suresh Kumar ^{[1
]}

Droge, Peter ^{[2
]}

Murugan, Priyatharshini ^{[2
]}

机构：

[1] Bharathidasan Univ, Dept Biotechnol, Tiruchirappalli, India

[2] Nanyang Technol Univ, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore

来源：

MICROBIAL PATHOGENESIS | 2021年 / 158卷

关键词：

Coronavirus disease 2019; Severe acute respiratory syndrome; Type I Interferon; Innate immunity; Interferon beta monotherapy; GENE-EXPRESSION; COVID-19; RIBAVIRIN; COMBINATION; INDUCTION; BINDING; EVASION; PROTEIN; TMPRSS2; CELLS;

D O I：

10.1016/j.micpath.2021.105105

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN alpha and beta) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN beta monotherapy against COVID-19.

引用

页数：10

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