NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

被引：16

作者：

Yin, Lei ^{[1
,2
]}

Bao, Fangping ^{[3
]}

Wu, Jing ^{[4
]}

Li, Kuanyu ^{[4
]}

机构：

[1] Shanghai Pudong New Area Peoples Hosp, Dept Anesthesiol, Shanghai 201200, Peoples R China

[2] Wannan Med Coll, Wuhu 241003, Anhui, Peoples R China

[3] Zhejiang Univ, Affiliated Hosp 1, Dept Anesthesiol, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

[4] Nanjing Univ, Sch Med, Jiangsu Key Lab Mol Med, Nanjing 2100093, Jiangsu, Peoples R China

来源：

JOURNAL OF NEUROINFLAMMATION | 2018年 / 15卷

关键词：

Isoflurane; Cognition; NLRP3; MCC950; Pyroptosis; MICE; INHIBITION; APOPTOSIS; PATHWAY; MODEL;

D O I：

10.1186/s12974-018-1299-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Wang Z et al. recently published a paper, titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment". The finding in this paper is consistent with our previous study on NLRP3-caspase-1 pathway. Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.

引用

页数：2

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