NLRP3 inflammasome-dependent pyroptosis is proposed to be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment

被引：16
|
作者：
Yin, Lei [1 ,2 ]
Bao, Fangping [3 ]
Wu, Jing [4 ]
Li, Kuanyu [4 ]
机构：
[1] Shanghai Pudong New Area Peoples Hosp, Dept Anesthesiol, Shanghai 201200, Peoples R China
[2] Wannan Med Coll, Wuhu 241003, Anhui, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Dept Anesthesiol, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
[4] Nanjing Univ, Sch Med, Jiangsu Key Lab Mol Med, Nanjing 2100093, Jiangsu, Peoples R China
来源：
JOURNAL OF NEUROINFLAMMATION | 2018年 / 15卷
关键词：
Isoflurane; Cognition; NLRP3; MCC950; Pyroptosis; MICE; INHIBITION; APOPTOSIS; PATHWAY; MODEL;
D O I：
10.1186/s12974-018-1299-x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Wang Z et al. recently published a paper, titled "Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment". The finding in this paper is consistent with our previous study on NLRP3-caspase-1 pathway. Here, we propose that NLRP3 inflammasome-dependent pyroptosis may be involved in the mechanism of age-dependent isoflurane-induced cognitive impairment and discuss that inhibiting NLRP3 inflammasome activation with a novel inhibitor MCC950 may ameliorate age-dependent isoflurane-induced neuro-inflammation.
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页数：2
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