Hypothesis: A promising effect of 5-HT1A receptor agonists in alleviating motor symptoms of Parkinson's disease

被引：0
作者：
Nayebi, A. M. [1 ]
机构：
[1] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Tabriz 51664, Iran
来源：
AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY | 2010年 / 4卷 / 06期
关键词：
5-HT1A receptor; motor symptom; Parkinson disease; DOPAMINE RELEASE; NUCLEUS-ACCUMBENS; SEROTONIN; RAT; STRIATUM; STIMULATION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Parkinson's disease (PD) is a disease caused by degeneration of dopaminergic neurons of substantia nigra, pars compacta. The fact that serotonergic system is also involved in PD has been raised from previous studies. Drugs that have effect on 5-HT1A receptors of basal ganglia might inhibit and facilitate serotonin and dopamine release, respectively. Augmentation of 5-HT1A agonists (e.g., buspirone) to anti-parkinsonian and neuroleptic drugs (D2 receptor blockers) may increase efficiency of anti-parkinsonian drugs and may also prevent motor complications induced by neuroleptic drugs.
引用
收藏
页码：289 / 290
页数：2
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