Cell-free DNA as a diagnostic marker for cancer: current insights

被引：95

作者：

Salvi, Samanta ^{[1
]}

Gurioli, Giorgia ^{[1
]}

De Giorgi, Ugo ^{[2
]}

Conteduca, Vincenza ^{[2
]}

Tedaldi, Gianluca ^{[1
]}

Calistri, Daniele ^{[1
]}

Casadio, Valentina ^{[1
]}

机构：

[1] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Biosci Lab, I-47014 Meldola, Italy

[2] IRCCS, Ist Sci Romagnolo Studio & Cura Tumori IRST, Dept Med Oncol, I-47014 Meldola, Italy

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

关键词：

cell-free DNA; diagnosis; cancer; liquid biopsy; CIRCULATING TUMOR DNA; FREE NUCLEIC-ACIDS; PLASMA DNA; BLADDER-CANCER; PROSTATE-CANCER; LUNG-CANCER; BREAST-CANCER; COPY-NUMBER; PROMOTER HYPERMETHYLATION; PERSONALIZED MEDICINE;

D O I：

10.2147/OTT.S100901

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The increasing knowledge of the molecular pathogenesis of cancer and the rapid development of new molecular techniques are promoting the study of early molecular alterations involved in cancer development in body fluids. Specific genetic and epigenetic alterations could be found in plasma, serum, and urine cell-free DNA (cfDNA) and could potentially be used as diagnostic biomarkers for several types of cancers. This review focuses on the role of cfDNA in diagnosis: a PubMed search was performed by selecting papers according to journal impact factor and robustness of statistical analysis. A comprehensive evaluation of " liquid biopsy", including cfDNA analysis, will be one of the critical challenges to better understand the early mechanisms of cancer development.

引用

页码：6549 / 6559

页数：11

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