Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

被引：893

作者：

Magee, Jeffrey A. ^{[1
,2
]}

Piskounova, Elena ^{[1
,2
]}

Morrison, Sean J. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Childrens Res Inst, Howard Hughes Med Inst, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA

来源：

CANCER CELL | 2012年 / 21卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; TUMOR-INITIATING CELLS; CHRONIC MYELOGENOUS LEUKEMIA; INTERNAL TANDEM DUPLICATION; CHILDRENS ONCOLOGY GROUP; EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE LYMPHOBLASTIC-LEUKEMIA; HUMAN COLORECTAL-CANCER; HIGH-RISK NEUROBLASTOMA; HUMAN OVARIAN-CANCER;

D O I：

10.1016/j.ccr.2012.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and nontumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells. In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients, the stem cell model may not be readily testable.

引用

页码：283 / 296

页数：14

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