The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment

被引：11

作者：

Wang, Xiwu ^{[1
]}

Zhou, Wenjun ^{[2
]}

Ye, Teng ^{[3
]}

Lin, Xiaodong ^{[1
]}

Zhang, Jie ^{[4
]}

Weiner, Michael W. ^{[5
]}

Aisen, Paul ^{[6
]}

Petersen, Ronald ^{[7
]}

Jack, Clifford R. ^{[7
]}

Jagust, William ^{[7
,8
]}

Trojanowki, John Q. ^{[9
,35
,89
]}

Toga, Arthur W. ^{[10
]}

Beckett, Laurel ^{[11
]}

Green, Robert C. ^{[12
]}

Saykin, Andrew J. ^{[13
]}

Morris, John ^{[14
]}

Shaw, Leslie M. ^{[15
,35
,89
]}

Khachaturian, Zaven ^{[16
]}

Sorensen, Greg ^{[17
]}

Carrillo, Maria ^{[18
]}

Kuller, Lew ^{[19
]}

Raichle, Marc ^{[14
]}

Paul, Steven ^{[20
]}

Davies, Peter ^{[21
]}

Fillit, Howard ^{[22
]}

Hefti, Franz ^{[23
]}

Holtzman, David ^{[14
]}

Mesulam, M. Marcel ^{[24
]}

Potter, William ^{[25
]}

Snyder, Peter ^{[26
]}

Logovinsky, Veronika

Lilly, Eli

Green, Robert C. ^{[12
]}

Montine, Tom ^{[27
]}

Petersen, Ronald ^{[7
]}

Aisen, Paul ^{[6
]}

Jimenez, Gustavo ^{[10
]}

Donohue, Michael ^{[10
,28
]}

Gessert, Devon ^{[10
]}

Harless, Kelly ^{[10
]}

Salazar, Jennifer ^{[10
]}

Cabrera, Yuliana ^{[10
]}

Walter, Sarah ^{[10
]}

Hergesheimer, Lindsey ^{[10
]}

Beckett, Laurel ^{[11
]}

Harvey, Danielle ^{[11
]}

Donohue, Michael ^{[10
,28
]}

Jack, Clifford R. ^{[7
]}

Bernstein, Matthew ^{[7
]}

Fox, Nick ^{[29
]}

机构：

[1] Wenzhou Seventh Peoples Hosp, Dept Psychiat, Wenzhou, Peoples R China

[2] Hangzhou Normal Univ, Dept Pathol, Hangzhou, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Affiliated Hosp 1, Dept Ultrasound, Wenzhou, Peoples R China

[4] Independent Res, Hangzhou, Peoples R China

[5] UC San Francisco, San Francisco, CA USA

[6] Univ Southern Calif, Los Angeles, CA USA

[7] Mayo Clin, Rochester, MI USA

[8] Univ Calif Berkeley, Berkeley, CA USA

[9] U Penn, Philadelphia, PA USA

[10] USC, Los Angeles, CA USA

[11] Univ Calif Davis, Davis, CA USA

[12] Harvard Med Sch, Brigham & Women's Hosp, Boston, MA 02115 USA

[13] Indiana Univ, Bloomington, IN 47405 USA

[14] Washington Univ St Louis, St Louis, MO USA

[15] Univ Penn, Philadelphia, PA 19104 USA

[16] Prevent Alzheimers Dis, Rockville, MD USA

[17] Siemens, Munich, Germany

[18] Alzheimers Assoc, Chicago, IL USA

[19] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[20] Cornell Univ, Ithaca, NY 14853 USA

[21] Yeshiva Univ, Albert Einstein Coll Med, New York, NY 10033 USA

[22] Drug Discovery Fdn, New York, NY USA

[23] Acumen Pharmaceuticals, Madurai, Tamil Nadu, India

[24] Northwestern Univ, Evanston, IL USA

[25] Natl Inst Mental Hlth, Bethesda, MD USA

[26] Brown Univ, Providence, RI 02912 USA

[27] Univ Washington, Seattle, WA 98195 USA

[28] Univ Calif San Diego, San Diego, CA USA

[29] Univ London, London, England

[30] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90024 USA

[31] UCSF MRI, San Francisco, CA USA

[32] Banner Alzheimers Inst, Phoenix, AZ USA

[33] Univ Utah, Salt Lake City, UT 84112 USA

[34] Univ Michigan, Ann Arbor, MI 48109 USA

[35] U Penn Sch Med, Philadelphia, PA USA

[36] UC Irvine, Irvine, CA USA

[37] NIA, Bethesda, MD 20892 USA

[38] Johns Hopkins Univ, Baltimore, MD 21218 USA

[39] Richard Frank Consulting, Washington, DC USA

[40] Oregon Hlth & Sci Univ, Portland, OR 97201 USA

[41] Univ Calif San Diego, San Diego, CA USA

[42] Baylor Coll Med, Houston, TX 77030 USA

[43] Columbia Univ, Med Ctr, New York, NY 10027 USA

[44] Univ Alabama Birmingham, Birmingham, AL USA

[45] Mt Sinai Med Ctr, Miami Beach, FL USA

[46] Rush Univ, Ctr Med, Chicago, IL USA

[47] Univ Vienna, Vienna, Austria

[48] NYU, New York, NY USA

[49] Duke Univ, Ctr Med, Durham, NC 27706 USA

[50] Univ Rochester, Rochester, NY 14627 USA

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2019年 / 11卷

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Alzheimer's disease; amnestic mild cognitive impairment; hippocampus; episodic memory; APOE epsilon 4; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DISEASE; MEMORY; BRAIN; RECOMMENDATIONS; RECRUITMENT; ACTIVATION; GENOTYPE;

D O I：

10.3389/fnagi.2019.00036

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To investigate whether APOE epsilon 4 affects the association of verbal memory with neurodegeneration presented by the hippocampal volume/intracranial volume ratio (HpVR). Methods: The study sample included 371 individuals with normal cognition (NC), 725 subjects with amnestic mild cognitive impairment (aMCI), and 251 patients with mild Alzheimer's disease (AD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) who underwent the rey auditory verbal learning test (RAVLT). Multiple linear regression models were conducted to assess the effect of the APOE epsilon 4*HpVR interaction on RAVLT in all subjects and in each diagnostic group adjusting for age, gender and educational attainment, and global cognition. Results: In all subjects, there was no significant APOE epsilon 4 x HpVR interaction for immediate recall or delayed recall (p > 0.05). However, in aMCI subjects, there was a significant APOE epsilon 4 x HpVR interaction for delayed recall (p = 0.008), but not immediate recall (p = 0.15). More specifically, the detrimental effect of APOE epsilon 4 on delayed recall altered by HpVR such that this effect was most evident among subjects with small to moderate HpVR, but this disadvantage was absent or even reversed among subjects with larger HpVR. No significant interaction was observed in the NC or AD group. Conclusion: These findings highlight a potential role of APOE epsilon 4 status in affecting the association of hippocampus size with delayed recall memory in the early stage of AD.

引用

页数：9

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