p-Terphenyl and Diterpenoid Metabolites from Endophytic Aspergillus sp YXf3

被引：60

作者：

Guo, Zhi Kai ^{[1
,2
,3
]}

Yan, Tong ^{[1
]}

Guo, Ye ^{[1
]}

Song, Yong Chun ^{[1
]}

Jiao, Rui Hua ^{[1
]}

Tan, Ren Xiang ^{[1
]}

Ge, Hui Ming ^{[1
]}

机构：

[1] Nanjing Univ, Inst Funct Biomol, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Peoples R China

[3] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Dev Trop Nat Prod, Haikou 571101, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 01期

关键词：

ALKALOIDS; CANDIDUS; FUNGUS;

D O I：

10.1021/np200321s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new p-terphenyl derivatives, named 4"-deoxy-3-hydroxyterphenyllin (1), 4"-deoxy-5'-desmethylterphenyllin (2), 5'-desmethylterphenyllin (3), 4"-deoxycandidusin A (4), 4,5-dimethoxycandidusin A (5), and terphenolide (6), four new diterpenoids with norcleistanthane (aspergiloid A (12) and aspergiloid B (13)), cleistanthane (aspergiloid C (14)), and isopimarane (aspergiloid D (15)) type skeletons, and five known p-terphenyl compounds (7-11) were isolated from the fermentation broth of the plant endophytic fungus Aspergillus sp. Their structures were elucidated on the basis of detailed spectroscopic analysis and by comparison of their NMR data with those reported in the literature. Compounds 4, 6, 7, and 9 displayed moderate neuraminidase inhibitory activity with IC50 values ranging from 4.34 to 9.17 mu M.

引用

页码：15 / 21

页数：7

共 27 条

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