Immunohistochemical expression of p15 (INK4B) and SMAD4 in advanced gastric cancer

被引：0

作者：

Sakellariou, Stratigoula ^{[1
]}

Liakakos, Theodore ^{[2
]}

Ghiconti, Ioanna ^{[4
]}

Hadjikokolis, Stamatis ^{[2
]}

Nakopoulou, Lydia ^{[3
]}

Pavlakis, Kitty ^{[3
]}

机构：

[1] G Gennimatas Hosp, Dept Pathol, Athens, Greece

[2] Univ Athens, Sch Med, Attikon Hosp, Surg Clin 3, GR-11527 Athens, Greece

[3] Univ Athens, Sch Med, Attikon Hosp, Dept Pathol 2, GR-11527 Athens, Greece

[4] Agia Olga Hosp, Dept Pathol, Athens, Greece

来源：

ANTICANCER RESEARCH | 2008年 / 28卷 / 2A期

关键词：

P15; SMAD4; gastric cancer; immunohistochemistry;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: P15 (a cyclin- D- kinase inhibitor) and SMAD4 (a signal transducer of the TGF-beta pathway) are two closely related proteins which may have an important role in gastric carcinogenesis. Materials and Methods: Sixty-three gastric carcinomas were studied. P15 and SMAD4 inummohistochemical expression was assessed with the DCS114.1 and BC/B8 mouse monoclonal antibodies, respectively. The results were tested for correlation with several clinicopathological parameters and patient survival. Results: Fifteen out of the 18 (83%) P15-positive tumors also exhibited preserved S-AL4D4 positivity (p = 0.001). Loss of P15 expression was more frequent in the intestinal type of carcinoma (p=0.047). The survival rates were significantly higher for patients with reduced SMAD4 expression, in cases of well- or moderately differentiated tumors (p=0.042). Conclusion: P15 gene silencing might be an important event in the tumorigenesis of gastric adenocarcinomas of the intestinal type. Smad4 may behave as a tumorpromoter in low grade tumors. The observed association between P15 and SAMD4 expression supports the inductive role of Smad4 in p15 transcription.

引用

页码：1079 / 1083

页数：5

共 33 条

[1] Inactivation of the p16 gene by hypermethylation and loss of heterozygosity in adenocarcinoma of the lung [J].