Education: A compassionate use of cefiderocol to treat osteomyelitis caused by an XDR Pseudomonas aeruginosa

被引：10

作者：

Chavda, A. ^{[1
]}

Gilchrist, M. ^{[1
]}

Samarasinghe, D. ^{[1
]}

机构：

[1] Imperial Coll Healthcare NHS Trust, St Marys Hosp, London W2 1NY, England

来源：

JAC-ANTIMICROBIAL RESISTANCE | 2021年 / 3卷

关键词：

D O I：

10.1093/jacamr/dlab054

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report a 59-year-old male with left leg osteomyelitis caused by an XDR Pseudomonas aeruginosa strain following a road traffic accident. Limited treatment options and adverse antimicrobial reaction led to consideration of cefiderocol together with appropriate surgical intervention. Improved bony remodelling over the tibia and fibula was observed with good bony alignment and no adverse features. Physiotherapy support was continued for 4 months following treatment, which resulted in good functional mobility, improved proprioception and full ability to bear weight. This case also adds to multiple reports that describe safe and successful use of cefiderocol to treat MDR, aerobic Gram-negative infections.

引用

页码：18 / 20

页数：3

共 4 条

[1] Long-Term Compassionate Use of Cefiderocol To Treat Chronic Osteomyelitis Caused by Extensively Drug-Resistant Pseudomonas aeruginosa and Extended-Spectrum-β-Lactamase-Producing Klebsiella pneumoniae in a Pediatric Patient [J].

Alamarat, Zain, I ;

Babic, Jessica ;

Tran, Truc T. ;

Wootton, Susan H. ;

Dinh, An Q. ;

Miller, William R. ;

Hanson, Blake ;

Wanger, Audrey ;

Gary, Joshua L. ;

Arias, Cesar A. ;

Perez, Norma .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2020, 64 (04)

[2] Case Report: Successful Rescue Therapy of Extensively Drug-Resistant Acinetobacter baumannii Osteomyelitis With Cefiderocol [J].

Dagher, Michael ;

Ruffin, Felicia ;

Marshall, Steven ;

Taracila, Magdalena ;

Bonomo, Robert A. ;

Reilly, Rachel ;

Fowler, Vance G. ;

Thaden, Joshua T. .

OPEN FORUM INFECTIOUS DISEASES, 2020, 7 (05)

[3] The definition of acute kidney injury and its use in practice [J].

Thomas, Mark E. ;

Blaine, Caroline ;

Dawnay, Anne ;

Devonald, Mark A. J. ;

Ftouh, Saoussen ;

Laing, Chris ;

Latchem, Susan ;

Lewington, Andrew ;

Milford, David V. ;

Ostermann, Marlies .

KIDNEY INTERNATIONAL, 2015, 87 (01) :62-73

[4] Cefiderocol: A Novel Agent for the Management of Multidrug-Resistant Gram-Negative Organisms [J].

Wu, Janet Y. ;

Srinivas, Pavithra ;

Pogue, Jason M. .

INFECTIOUS DISEASES AND THERAPY, 2020, 9 (01) :17-40

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