The Regulation of NF-κB Subunits by Phosphorylation

被引：602

作者：

Christian, Frank ^{[1
]}

Smith, Emma L. ^{[1
]}

Carmody, Ruaidhri J. ^{[1
]}

机构：

[1] Univ Glasgow, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat, Ctr Immunobiol, Glasgow G12 8TA, Lanark, Scotland

来源：

CELLS | 2016年 / 5卷 / 01期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

NF-kappa B; phosphorylation; kinase; transcription factor; NECROSIS-FACTOR-ALPHA; P105 REQUIRES PHOSPHORYLATION; A RECOGNITION SEQUENCE; T-CELL COSTIMULATION; PROTEIN-KINASE; TRANSCRIPTIONAL ACTIVITY; P65; SUBUNIT; NF-KAPPA-B1; P105; IKK-EPSILON; C-REL;

D O I：

10.3390/cells5010012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The NF-kappa B transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-kappa B regulates the transcription of genes that control inflammation, immune cell development, cell cycle, proliferation, and cell death. The fundamental role that NF-kappa B plays in key physiological processes makes it an important factor in determining health and disease. The importance of NF-kappa B in tissue homeostasis and immunity has frustrated therapeutic approaches aimed at inhibiting NF-kappa B activation. However, significant research efforts have revealed the crucial contribution of NF-kappa B phosphorylation to controlling NF-kappa B directed transactivation. Importantly, NF-kappa B phosphorylation controls transcription in a gene-specific manner, offering new opportunities to selectively target NF-kappa B for therapeutic benefit. This review will focus on the phosphorylation of the NF-kappa B subunits and the impact on NF-kappa B function.

引用

页数：19

共 121 条

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