Molecules That Modulate Apaf-1 Activity

被引:22
作者
Perez-Paya, Enrique [1 ,2 ]
Orzaez, Mar [1 ]
Mondragon, Laura [1 ]
Wolan, Dennis [3 ]
Wells, James A. [3 ]
Messeguer, Angel [4 ]
Vicent, Maria J. [5 ]
机构
[1] Ctr Invest Principe Felipe, Dept Med Chem, Peptide & Prot Lab, E-46012 Valencia, Spain
[2] IBV CSIC, Inst Biomed Valencia, Valencia, Spain
[3] Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA USA
[4] IQAC CSIC, Dept Chem & Biomol Nanotechnol, Barcelona, Spain
[5] Ctr Invest Principe Felipe, Dept Med Chem, Polymer Therapeut Lab, E-46012 Valencia, Spain
关键词
apoptosis; apoptosome; Apaf-1; modulators; nanomedicine; ACTIVATING FACTOR-1 APAF-1; PROGRAMMED CELL-DEATH; BCL-2; FAMILY-MEMBERS; CYTOCHROME-C; CASPASE ACTIVATION; APAF-1/CASPASE-9; APOPTOSOME; NUCLEOTIDE EXCHANGE; OVARIAN-CANCER; MEDIATED OLIGOMERIZATION; PROTEOLYTIC CLEAVAGE;
D O I
10.1002/med.20198
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Programmed cell death, apoptosis, is a highly regulated cellular pathway, responsible for the elimination of cells in the organism that are no longer needed or extensively damaged. Defects in the regulation of apoptosis could be at the molecular basis of different diseases, either when it is insufficient or excessive. The formation of the macromolecular complex, apoptosome, is a key event in this pathway, which has also been defined as the intrinsic apoptosis pathway. The apoptosome is a holoenzyme multiprotein complex formed by cytochrome c-activated apoptotic protease-activating factor (Apaf-1), dATP, and procaspase-9. Recent studies have produced a wealth of information about the regulation and functions of Apaf-1, but additional studies aimed at elucidating its role as a signaling device at the crosstalk between different signaling pathways are needed to take advantage for the development of modulators of apoptosis pathways and possible therapeutic applications. (C) 2010 Wiley Periodicals, Inc. Med Res Rev, 31, No. 4, 649-675, 2011
引用
收藏
页码:649 / 675
页数:27
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