VEGF as a potential target for therapeutic intervention in depression

被引：131
作者：
Warner-Schmidt, Jennifer L. [1 ]
Duman, Ronald S. [2 ]
机构：
[1] Rockefeller Univ, New York, NY 10065 USA
[2] Yale Univ, New Haven, CT 06508 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2008年 / 8卷 / 01期
关键词：
D O I：
10.1016/j.coph.2007.10.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and behavioral antidepressant responses. VEGF is a potent mitogen and survival factor for endothelial cells (ECs) and neurons, and modulator of synaptic transmission. Because VEGF has been implicated in a variety of diseases, understanding the molecular and cellular specificity of antidepressant-induced VEGF will be crucial to determine its potential as a therapeutic target in depression.
引用
收藏
页码：14 / 19
页数：6
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