Organolithium-mediated conversion of β-functionalised aziridines into alkynyl amino alcohols and diamines

被引：20

作者：

Huang, JH ^{[1
]}

O'Brien, P ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 45期

关键词：

D O I：

10.1039/b510920e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct conversion of dihydrofuran and dihydropyrrole N-triisopropylbenzenesulfonyl aziridines into alkynyl amino alcohols and diamines respectively can be achieved using 3 equiv. sec-butyllithium-PMDETA in THF; use of n-butyllithium and (-)-sparteine in Et2O gave an alkynyl amino alcohol in 60% ee.

引用

页码：5696 / 5698

页数：3

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