Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure:: An independent predictor of mortality

被引:63
作者
Frantz, S. [1 ]
Stoerk, S. [1 ]
Michels, K. [1 ]
Eigenthaler, M. [1 ]
Ertl, G. [1 ]
Bauersachs, J. [1 ]
Angermann, C. E. [1 ]
机构
[1] Univ Wurzburg, Dept Internal Med 1, Ctr Cardiovasc Med, D-97070 Wurzburg, Germany
关键词
heart failure; matrix metalloproteinase; tissue inhibitor of metalloproteinases; prognosis;
D O I
10.1016/j.ejheart.2008.02.015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF). Aims: We investigated the association of plasma levels of soluble MMP-9 and TIMP-1 with clinical, laboratory and echocardiographic parameters and estimated their prognostic value in the prediction of all-cause death. Methods: MMP-9, TIMP-1, tumour necrosis factor-alpha, and amino-terminal pro-brain natriuretic peptide were measured in 249 consecutively enrolled CHF patients and 74 healthy individuals. Results: After adjustment forage, sex and creatinine, levels of TIMP-1 (1640 vs. 735 ng/ml, P<0.001) but not MMP-9 were elevated in CHF patients compared to controls. During a median follow-up period of 2.5 years, 66 patients (27%) died. In multivariable Cox regression models TIMP-1 but not MMP-9 emerged as an independent predictor of all-cause death (hazard ratio per tertile, 3.5; 95% confidence interval [CI], 2.2-5.1). In addition to the full set of univariately predictive clinical and serological markers, information on TIMP-1 significantly increased the area under the receiver operating characteristic curve from 0.77 (95% CI, 0.71-0.84) to 0.87 (95% CI, 0.82-0.92). Conclusion: In stable CHF patients, TIMP-1 but not MMP-9 is of independent and incremental value regarding the prediction of all-cause death. (C) 2008 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:388 / 395
页数:8
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