Antileishmanial and antifungal activities of xanthanolides isolated from Xanthium macrocarpum

被引：58

作者：

Lavault, M

Landreau, A

Larcher, G

Bouchara, JP

Pagniez, F

Le Pape, P

Richomme, P

机构：

[1] UFR Sci Pharmaceut & Ingn Sante, SONAS, UPRESEA 921, Angers, France

[2] Ctr Hosp Univ, Grp Etude Interact Hote Parasite, UPRESEA 3142, Lab Parasitol Mycol, Angers, France

[3] Fac Pharm, Lab Pharasitol & Mycol Med, UPRES EA 1155, F-44035 Nantes, France

来源：

FITOTERAPIA | 2005年 / 76卷 / 3-4期

关键词：

Xanthium macrocarpum; xanthanolides; antifungal activity; antileishmanial activity;

D O I：

10.1016/j.fitote.2005.03.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven xanthanolides, xanthinosin, xanthatin, 4-hydroxyxanthinosin, xanthinin, 4-epiisoxanthanol, 4-epixanthanol, 2-hydroxyxanthinosin and 4-oxobedfordia acid, were isolated from the fruits of Xanthium macrocatpum. A valuation of the antifungal activity of these xanthanolides against Candida albicans, Candida glabrata and Aspeirgillus fumigatus and of their antileishmanial activity against Leishmania infantum and Leishmania mexicana is presented. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：363 / 366

页数：4

共 19 条

[1] New sources and antifungal activity of sesquiterpene lactones [J].