Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males

被引：30

作者：

Apostolopoulou, Maria ^{[1
,2
,3
,4
]}

Mastrototaro, Lucia ^{[3
,4
]}

Hartwig, Sonja ^{[4
,5
]}

Pesta, Dominik ^{[3
,4
]}

Strassburger, Klaus ^{[4
,6
]}

de Filippo, Elisabetta ^{[3
,4
]}

Jelenik, Tomas ^{[3
,4
]}

Karusheva, Yanislava ^{[3
,4
]}

Gancheva, Sofiya ^{[1
,2
,3
,4
]}

Markgraf, Daniel ^{[3
,4
]}

Herder, Christian ^{[1
,2
,3
,4
]}

Nair, K. Sreekumaran ^{[7
]}

Reichert, Andreas S. ^{[8
,9
]}

Lehr, Stefan ^{[4
,5
]}

Mussig, Karsten ^{[1
,2
,3
,4
]}

Al-Hasani, Hadi ^{[4
,5
]}

Szendroedi, Julia ^{[1
,2
,3
,4
,10
]}

Roden, Michael ^{[1
,2
,3
,4
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany

[2] Heinrich Heine Univ Dusseldorf, Univ Hosp, Dusseldorf, Germany

[3] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[4] German Ctr Diabet Res, Partner Dusseldorf, Munich, Germany

[5] Heinrich Heine Univ Dusseldorf, Inst Clin Biochem & Pathobiochem, Leibniz Ctr Diabet Res, German Diabet Ctr, Dusseldorf, Germany

[6] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Inst Biometr & Epidemiol, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[7] Mayo Clin, Div Endocrinol Diabet & Nutr, Rochester, MN USA

[8] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Biochem & Mol Biol 1, Dusseldorf, Germany

[9] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany

[10] Heidelberg Univ, Dept Internal Med, Heidelberg, Germany

来源：

SCIENCE ADVANCES | 2021年 / 7卷 / 41期

关键词：

MUSCLE ATP SYNTHESIS; SKELETAL-MUSCLE; MITOCHONDRIAL BIOGENESIS; OXIDATIVE CAPACITY; LOW-VOLUME; EXERCISE; INFLAMMATION; INDIVIDUALS; RISK; ACTIVATION;

D O I：

10.1126/sciadv.abi9551

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO2 max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO2 max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase C epsilon activity) or inflammatory (nuclear factor kappa B) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans.

引用

页数：14

共 86 条

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