Abnormal frontal cortex white matter connections in bipolar disorder: A DTI tractography study

被引:93
作者
Lin, Fuchun [1 ]
Weng, Shenhong [2 ]
Xie, Baojun [3 ]
Wu, Guangyao [4 ]
Lei, Hao [1 ]
机构
[1] Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China
[3] Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan 430060, Peoples R China
[4] Wuhan Univ, Zhongnan Hosp, Dept Radiol, Wuhan 430071, Peoples R China
关键词
Bipolar disorder; Fiber tracts; Frontal cortex; Fractional anisotropy; DTI tractography; SUBGENUAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; DIFFUSION-TENSOR; MICROSTRUCTURAL ABNORMALITIES; SCHIZOPHRENIA; INTEGRITY; PATHOLOGY; BRAIN; MRI; TRACKING;
D O I
10.1016/j.jad.2010.12.018
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: In bipolar disorder, white matter abnormalities have been reported with region-of-interest and voxel-based methods; however, deficits in specific white matter tracts cannot be localized by these methods. Therefore, in this study, we aimed to investigate the white matter tracts that mediate connectivity of the frontal cortex using diffusion tensor imaging (DTI) tractography. Methods: Eighteen patients with bipolar disorder and sixteen age- and gender-matched healthy subjects underwent DTI examinations. Frontal cortex white matter tracts, including the anterior thalamic radiation (AIR), uncinate fasciculus (UF), superior longitudinal fasciculus (SLF), cingulum, and inferior fronto-occipital fasciculus (IFO) were reconstructed by DTI tractography, and we calculated the mean fractional anisotropy (FA) for each fiber tract. The values were compared between groups by repeated measures analysis of variance with age and gender as covariates, which allowed us to investigate significant differences between the tracts. Results: When compared with healthy controls, the patients with bipolar disorder showed significantly decreased FA in the ATR and UF, and a trend towards lower FA in the SLF and cingulum. However, there were no FA differences between groups in the IFO. Conclusions: Our study indicates that bipolar patients show abnormalities within white matter tracts connecting the frontal cortex with the temporal and parietal cortices and the fronto-subcortical circuits. These findings suggest that alterations in the connectivity of white matter tracts in the frontal cortex might contribute to the neuropathology of bipolar disorder. Crown Copyright (C) 2010 Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:299 / 306
页数:8
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