Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: An update by meta-analysis

被引：55

作者：

Zhang, Jie ^{[1
]}

Li, Wei ^{[1
]}

Liu, Jiaming ^{[1
]}

Wu, Wenhe ^{[1
]}

Ouyang, Houxian ^{[1
]}

Zhang, Qingqing ^{[1
]}

Wang, Yue ^{[1
]}

Liu, Libin ^{[1
]}

Yang, Rongrong ^{[1
]}

Liu, Xiaoting ^{[1
]}

Meng, Qinghe ^{[1
]}

Lu, Jianxin ^{[1
]}

机构：

[1] Wenzhou Med Coll, Key Lab Lab Med, Minist Educ, Zhejiang Prov Key Lab Med Genet, Wenzhou 325035, Zhejiang, Peoples R China

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2012年 / 355卷 / 01期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Type 1 diabetes mellitus; Vitamin D receptor gene; Polymorphisms; Meta-analysis; BONE-MINERAL DENSITY; SUSCEPTIBILITY; ASSOCIATION; ONSET; FOKI;

D O I：

10.1016/j.mce.2012.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Four well known polymorphisms (BsmI, FokI, ApaI, TaqI) in the VDR gene have been implicated in susceptibility to type 1 diabetes mellitus (T1DM), but the results to date have been inconclusive. The aim of this study was to investigate the association between polymorphisms in the VDR gene and T1DM risk by meta-analysis. A total of 57 case-control studies in 26 published studies were included. The results indicated that the BsmI polymorphism is associated with increased risk of T1DM (BB + Bb vs. bb: OR = 1.30, 95% CI = 1.03-1.63), while the FokI, ApaI and TaqI polymorphisms were not. In the subgroup analysis by ethnicity, the increased risk of T1DM remained in the Asian subgroup for the BsmI polymorphism; whereas no significant association was found in other populations for other polymorphisms. Results from the current study suggest that the BsmI polymorphism is associated with increased risk of T1DM, especially in Asians. Further studies are needed to confirm our results. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：135 / 142

页数：8

共 38 条

[1]

[Anonymous], 2005, ZHONG GUO LIN CHUANG

[2] VDR gene polymorphism at exon 2 start codon (FokI) may have influenced Type 1 diabetes mellitus susceptibility in two Spanish populations [J].