SARS-CoV-2 Proteins Induce Endotoxin Tolerance Hallmarks: A Demonstration in Patients with COVID-19

被引：7

作者：

Avendano-Ortiz, Jose ^{[1
,2
]}

Lozano-Rodriguez, Roberto ^{[1
,2
]}

Martin-Quiros, Alejandro ^{[3
,4
]}

Maroun-Eid, Charbel ^{[1
]}

Terron-Arcos, Veronica ^{[1
,2
]}

Montalban-Hernandez, Karla ^{[1
,2
]}

Valentin, Jaime ^{[1
,2
]}

Munoz del Val, Elena ^{[1
,3
,4
]}

Garcia-Garrido, Miguel A. ^{[1
]}

del Balzo-Castillo, Alvaro ^{[1
,3
,4
]}

Carlos Casalvilla-Duenas, Jose ^{[1
,2
]}

Peinado, Maria ^{[1
,3
,4
]}

Gomez, Laura ^{[1
,3
,4
]}

Herrero-Benito, Carmen ^{[1
]}

Rubio, Carolina ^{[1
,2
]}

Cubillos-Zapata, Carolina ^{[5
]}

Pascual-Iglesias, Alejandro ^{[1
,2
]}

del Fresno, Carlos ^{[1
,2
]}

Aguirre, Luis A. ^{[1
,2
]}

Lopez-Collazo, Eduardo ^{[1
,2
,5
]}

机构：

[1] La Paz Univ Hosp, Hosp La Paz, Innate Immun Grp, Inst Hlth Res, Madrid, Spain

[2] La Paz Univ Hosp, Hosp La Paz, Tumor Immunol Lab, Inst Hlth Res, Madrid, Spain

[3] La Paz Univ Hosp, Hosp La Paz, Emergency Dept, Inst Hlth Res, Madrid, Spain

[4] La Paz Univ Hosp, Hosp La Paz, Emergent Pathol Res Grp, Inst Hlth Res, Madrid, Spain

[5] Ctr Biomed Res Network, Madrid, Spain

来源：

JOURNAL OF IMMUNOLOGY | 2021年 / 207卷 / 01期

关键词：

ACUTE RESPIRATORY SYNDROME; CORONAVIRUS DISEASE 2019; HUMAN MONOCYTES; IMMUNE-RESPONSE; LIPOPOLYSACCHARIDE; CELLS;

D O I：

10.4049/jimmunol.2001449

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to a large number of reported cohorts, sepsis has been observed in nearly all deceased patients with COVID-19. We and others have described sepsis, among other pathologies, to be an endotoxin tolerance (ET) -related disease. In this study, we demonstrate that the culture of human blood cells from healthy volunteers in the presence of SARS-CoV-2 proteins induced ET hallmarks, including impairment of proinflammatory cytokine production, low MHC class II (HLA-DR) expression, poor T cell proliferation, and enhancing of both phagocytosis and tissue remodeling. Moreover, we report the presence of SARS-CoV-2 blood circulating proteins in patients with COVID-19 and how these levels correlate with an ET status, the viral RNA presence of SARS-CoV-2 in plasma, as well as with an increase in the proportion of patients with secondary infections.

引用

页码：162 / +

页数：14

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