The study of phospholipid synthesis in liver of mice with alloxan diabetes

The essential decrease of the rate of turnover of phosphatidic acids (PA), polyglycerophosphates (PGP) and their lysoderivatives (LPGP), sphinigomyelin (SM) and lysophosphatidylcholine (LPC), phosphatidyletnanolamine (PEA) was found in male mice of BALB/C Strain with subacute alloxan diabetes (glucose concentration in the blood was not less than 14 mmol/l) during examination of phospholipid metabolism in the liver by the rate of H-3-acetate and C-14-palmitate incorporation into corresponding chromatographic phospholipid fractions. On the contrary, turnover of phosphatidilcholine (PC) significantly increased. The of main structural phospholipid components of hepatocyte cellular membranes -PEA and PC - were found to be decreased by 41 and 32%, respectively. LPGP and PA levels decreased to a lesser extent. The level of PGP, SM, phospilatidylinositol and LPG did not differ from the control level.