The Toll-like receptors and its signalling transduction pathways

被引：0
|
作者：
Wang, LH
Si, YH
Jiao, BH
机构：
[1] Second Mil Med Univ, Fac Basic Med Sci, Dept Hlth Toxicol, Shanghai 200433, Peoples R China
[2] China Pharmaceut Univ, Coll Biopharmaceut, Nanjing 210009, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2001年 / 28卷 / 03期
关键词：
pathogen recognition; TLRs; IL-1R1; signaling transduction;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The most ancient host defense system found in mammals, insects and plants are mediated by Toll-like receptors (TLRs) and its associated signaling pathways of NK-kappaB. Signaling pathways of downstream of TLR2 or TLR4 complex which includes ligands (LPS or another), CD14 or/and MD-2 and receptor itself recruit MyD88 to activate the autophosphorylation of IRAK. The oligomerization of TNF receptor-associated factor 6 (TRAF6) is necessary to initiate the activation of NF-kappaB-inducing kinase (NIK) which finally leads to the activation of NF-kappaB via the Toll/IL-1-receptor homologous region (TIR) domain.
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收藏
页码：304 / 308
页数：5
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